Mass transport model through the skin by microencapsulation system

Autor: Manel Lis, Meritxell Martí, Núria Carreras, Cristina Alonso
Přispěvatelé: Universitat Politècnica de Catalunya. Departament d'Enginyeria Química, Universitat Politècnica de Catalunya. POLQUITEX - Materials Polimérics i Química Téxtil
Rok vydání: 2015
Předmět:
Mass transport
Enginyeria tèxtil ::Teixits::Teixits mèdics [Àrees temàtiques de la UPC]
Swine
Nanoestructures -- Ús terapèutic
Pharmaceutical Science
Ibuprofen
biofunctional textile substrates
Drug Delivery Systems
Colloid and Surface Chemistry
Skin
ibuprofen
Transdermal
Microencapsulation--Technological innovations
integumentary system
in vitro skin delivery
Textiles
Anti-Inflammatory Agents
Non-Steroidal
microcapsules
medicine.anatomical_structure
Drug delivery
Percutaneous absorption
microencapsulation
medicine.drug
skin
medicine.medical_specialty
Materials science
Drug Compounding
Skin Absorption
Capsules
Bioengineering
Administration
Cutaneous
Models
Biological
Permeability
medicine
Stratum corneum
Animals
Physical and Theoretical Chemistry
Teixits i tèxtils -- Innovacions tecnològiques
Organic Chemistry
Penetration (firestop)
Ibuprofen--therapeutic use
Drug delivery systems--Technological innovations
Medicaments -- Administració
Surgery
Kinetics
percutaneous absorption
Skin penetration
Enginyeria química::Indústries químiques::Química tèxtil [Àrees temàtiques de la UPC]
Skin--Permeability
mathematical model
Biomedical engineering
Zdroj: UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Recercat. Dipósit de la Recerca de Catalunya
Universitat Jaume I
ISSN: 1464-5246
0265-2048
DOI: 10.3109/02652048.2015.1028495
Popis: Skin drug delivery can be subdivided into topical and transdermal administration. Transdermal administration can take advantage of chemical and physical strategies that can improve skin permeability and allow drug penetration. In this study, the development of a skin penetration profile was carried out by an in vitro technique for a microencapsulated system of ibuprofen. Release experiments were performed using percutaneous absorption tests to determine the evolution of the principle present in each of the different skin compartments as a function of time. A general kinetic model for a microencapsulated structure as a mass transport system through the skin was applied: [Formula: see text] This model could predict the penetration profile of encapsulated substances through skin from biofunctional textiles as well as estimate the dosage profile of the active principle. The apparent diffusion coefficients found were 1.20 × 10(-7 )cm/s for the stratum corneum and higher for the rest of the skin 6.67 × 10(-6 )cm/s.
Databáze: OpenAIRE
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