Acebutolol and coronary artery surgery
| Autor: | M. G. Sankey, I. J. Reece, C. M. Kaye, N. J. Odom, G. M. M. Thoms |
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| Rok vydání: | 1982 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Premedication Metabolite medicine.medical_treatment Acebutolol Intraoperative Period chemistry.chemical_compound Humans Medicine Intubation Postoperative Period Coronary Artery Bypass business.industry Antagonist Plasma levels Middle Aged Surgery Regimen Anesthesiology and Pain Medicine chemistry Diacetolol Anesthesia business medicine.drug |
| Zdroj: | Anaesthesia. 37:1078-1083 |
| ISSN: | 1365-2044 0003-2409 |
| DOI: | 10.1111/j.1365-2044.1982.tb01751.x |
| Popis: | Summary Plasma levels of acebutolol and its major human metabolite, diacetolol, were determined before, during and after aortocoronary bypass grafting in 10 patients who had received a chronic oral regimen of acebutolol 200 mg t.d.s. for at least 6 days before surgery, a 200 mg dose with the premedication and 5–10 mg intravenously immediately before intubation. It was found that this regimen produced beta-adrenoceplor antagonist levels which were within the range in which attenuation of hypertension and tachydysrhythmiu occurs. These effective plasma levels were sustained throughout surgery and persisted into the early recovery period. |
| Databáze: | OpenAIRE |
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