Virtual Histology Intravascular Ultrasound Compared With Optical Coherence Tomography for Identification of Thin-Cap Fibroatheroma
| Autor: | Kenichi Komukai, Yasushi Ino, Yoshiki Matsuo, Takashi Kubo, Xiaofan Wu, So-Yeon Choi, Masato Mizukoshi, Hironori Kitabata, Keizo Kimura, Takashi Tanimoto, Hideharu Akagi, Toshio Imanishi, Tadao Yamamoto, Takashi Akasaka, Nobuo Nakamura, Yasushi Okumoto |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Coronary Angiography Angina Pectoris Coronary artery disease Virtual histology intravascular ultrasound Optical coherence tomography Positive predicative value Intravascular ultrasound medicine Humans cardiovascular diseases Ultrasonography Interventional Aged medicine.diagnostic_test business.industry Fibrous cap General Medicine medicine.disease Coronary Vessels Plaque Atherosclerotic Thin-cap fibroatheroma medicine.anatomical_structure Female Tomography Radiology Cardiology and Cardiovascular Medicine business Tomography Optical Coherence |
| Zdroj: | International Heart Journal. 52:175-179 |
| ISSN: | 1349-3299 1349-2365 |
| DOI: | 10.1536/ihj.52.175 |
| Popis: | Virtual histology intravascular ultrasound (VH-IVUS) allows detailed assessment of plaque composition in the clinical setting. Optical coherence tomography (OCT) has been developed as a high-resolution imaging method, which might be a promising technique to identify thin-cap fibroatheroma (TCFA) in vivo. The purpose of the present study was to evaluate the diagnostic accuracy of VH-IVUS to identify TCFA as determined by OCT.We examined 96 target lesions in patients with stable angina pectoris by using VH-IVUS and OCT. VH-IVUS derived TCFA was defined as a focal necrotic core-rich lesion without evident overlying fibrous tissue. OCT derived TCFA was defined as a plaque with a fibrous cap of < 65 µm. VH-IVUS correctly identified 16 TCFA and 67 non-TCFA but misclassified 2 TCFA and 11 non-TCFA as determined by OCT. The sensitivity, specificity, and positive and negative predictive values of VH-IVUS to identify TCFA as determined by OCT were 89%, 86%, 59%, and 97%, respectively.VH-IVUS showed an acceptable sensitivity and specificity to identify TCFA as determined by OCT. Although the positive predictive value was low reflecting a high number of false positives, the negative predictive value was notably high. Our results suggest a potential role for VH-IVUS to exclude high risk lesions for future coronary events. |
| Databáze: | OpenAIRE |
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