Differentiation of atrial fibrillation progression phenotypes using Troponin T
| Autor: | Holger Thiele, Joachim Thiery, Ronny Baber, Jelena Kornej, Gerhard Hindricks, Ralph Burkhardt, Anja Willenberg, Petra Büttner, Alexander Thaler, Yoon Ju Bae, Andreas Hagendorff, Samira Zeynalova, Markus Loeffler |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Renal function Catheter ablation 030204 cardiovascular system & hematology Cohort Studies 03 medical and health sciences 0302 clinical medicine Troponin T Predictive Value of Tests Internal medicine Atrial Fibrillation Epidemiology medicine Humans 030212 general & internal medicine Aged Ejection fraction business.industry Atrial fibrillation Middle Aged medicine.disease Phenotype ROC Curve Cohort Catheter Ablation Disease Progression Cardiology Biomarker (medicine) Female Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | International Journal of Cardiology. 297:61-65 |
| ISSN: | 0167-5273 |
| DOI: | 10.1016/j.ijcard.2019.09.006 |
| Popis: | Electro-anatomical remodeling in atrial fibrillation (AF) is associated with disease initiation and progression. Troponin T (TropT) - a specific biomarker for myocardial damage - is associated with AF incidence. However, its association with AF progression is understudied. The aim of the current analysis was to investigate the association between TropT and AF progression phenotypes: persistent AF and left atrial low voltage areas (LVAs).Patients undergoing first AF ablation were included into analyses. LVAs were determined using high-density maps and defined as0.5 mV. Blood samples from femoral vein were collected before catheter ablation. The analysis of TropT serum concentrations was performed using a high-sensitive assay from Roche Diagnostics. Biomarkers, clinical, anthropometric and echocardiographic data were compared with healthy individuals from the epidemiological cohort.The study included 824 healthy individuals without overt cardiovascular disease (54 ± 10 years, 40% males) from epidemiological cohort and 241 AF patients (64 ± 11 years, 59% males, 59% persistent AF, 27% LVAs). Patients with AF had higher TropT levels and larger left atrium (LA), while healthy individuals had better renal function and ejection fraction (all p 0.001). In clinical cohort, there were significant differences between TropT levels according to AF progression groups: paroxysmal AF without/with LVAs (n = 86/12), persistent AF without/with LVAs (n = 90/53): means 7.3, 12.9, 8.4, 11.3 pg/ml, p 0.001, respectively. Similar findings were observed for LA and renal function (all p 0.001). On ROC analysis, TropT significantly predicted LVAs (AUC 0.675, 95%CI 0.598-0.752, p 0.001) in AF patients.TropT may be useful to differentiate AF progression phenotypes. |
| Databáze: | OpenAIRE |
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