Genome analysis of Bifidobacterium bifidum PRL2010 reveals metabolic pathways for host-derived glycan foraging
| Autor: | Marco Ventura, Douwe van Sinderen, Massimo Delledonne, Abelardo Margolles, Imke Mulder, Vanessa Giubellini, Aldert Zomer, Marco R. Oggioni, Alberto Ferrarini, Francesca Bottacini, Denise Kelly, David A. Mills, Jaehan Kim, Gerald F. Fitzgerald, Borja Sánchez, Pedro M. Coutinho, Francesca Turroni, Bernard Henrissat, Elena Foroni, Alessandro Bidossi |
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| Přispěvatelé: | National Institute of Child Health and Human Development (US), Science Foundation Ireland, Turroni F, Bottacini F, Foroni E, Mulder I, Kim JH, Zomer A, Sánchez B, Bidossi A, Ferrarini A, Giubellini V, Delledonne M, Henrissat B, Coutinho P, Oggioni M, Fitzgerald GF, Mills D, Margolles A, Kelly D, van Sinderen D, Ventura M |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Glycan
genomica funzionale ved/biology.organism_classification_rank.species Molecular Sequence Data Microbiologia Genome digestive system genoma sequenziamento Feces fluids and secretions Probiotici Polysaccharides Humans Gene Bifidobacterium Genetics Multidisciplinary Bifidobacterium bifidum biology ved/biology Gene Expression Profiling Mucin Infant Newborn Mucins food and beverages Genomics Biological Sciences biology.organism_classification Gene expression profiling Intestines Biochemistry Multigene Family Proteome Host-Pathogen Interactions biology.protein Genomica Genome Bacterial Metabolic Networks and Pathways |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| Popis: | Turroni, Francesca et al. The human intestine is densely populated by a microbial consortium whose metabolic activities are influenced by, among others, bifidobacteria. However, the genetic basis of adaptation of bifidobacteria to the human gut is poorly understood. Analysis of the 2,214,650-bp genome of Bifidobacterium bifidum PRL2010, a strain isolated from infant stool, revealed a nutrient-acquisition strategy that targets host-derived glycans, such as those present in mucin. Proteome and transcriptome profiling revealed a set of chromosomal loci responsible for mucin metabolism that appear to be under common transcriptional control and with predicted functions that allow degradation of various O-linked glycans in mucin. Conservation of the latter gene clusters in various B. bifidum strains supports the notion that host-derived glycan catabolism is an important colonization factor for B. bifidum with concomitant impact on intestinal microbiota ecology. This work was supported by National Institutes of Health–National Institute of Child Health and Human Development Grant 1R01HD061923 (to D.M.). D.v.S., A.Z., and F.B. are members of the Alimentary Pharmabiotic Centre, a Center for Science and Technology funded by Science Foundation Ireland, through the Irish Government’s National Development Plan Grant 07/CE/B1368. |
| Databáze: | OpenAIRE |
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