Associations between three common single nucleotide polymorphisms (rs266729, rs2241766, and rs1501299) of ADIPOQ and cardiovascular disease: a meta-analysis
| Autor: | Changgui Kou, Yi Cheng, Yong Li, Shuang Qiu, Ri Li, Yunkai Liu, Yaqin Yu, Joseph Sam Kanu, Jikang Shi, Yawen Liu, Ye Bai, Yulu Gu |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Endocrinology Diabetes and Metabolism Clinical Biochemistry Single-nucleotide polymorphism Subgroup analysis 030204 cardiovascular system & hematology Cochrane Library Polymorphism Single Nucleotide Association 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Genetic model medicine ADIPOQ Humans Genetic Predisposition to Disease Allele lcsh:RC620-627 Genetic Association Studies business.industry Research Biochemistry (medical) Confounding Heterozygote advantage Single nucleotide polymorphisms Cardiovascular disease Meta-analysis lcsh:Nutritional diseases. Deficiency diseases 030104 developmental biology Cardiovascular Diseases Adiponectin business |
| Zdroj: | Lipids in Health and Disease, Vol 17, Iss 1, Pp 1-21 (2018) Lipids in Health and Disease |
| Popis: | Background Inconsistencies have existed in research findings on the association between cardiovascular disease (CVD) and single nucleotide polymorphisms (SNPs) of ADIPOQ, triggering this up-to-date meta-analysis. Methods We searched for relevant studies in PubMed, EMBASE, Cochrane Library, CNKI, CBM, VIP, and WanFang databases up to 1st July 2017. We included 19,106 cases and 31,629 controls from 65 published articles in this meta-analysis. STATA 12.0 software was used for all statistical analyses. Results Our results showed that rs266729 polymorphism was associated with the increased risk of CVD in dominant model or in heterozygote model; rs2241766 polymorphism was associated with the increased risk of CVD in the genetic models (allelic, dominant, recessive, heterozygote, and homozygote). In subgroup analysis, significant associations were found in different subgroups with the three SNPs. Meta-regression and subgroup analysis showed that heterogeneity might be explained by other confounding factors. Sensitivity analysis revealed that the results of our meta-analysis were stable and robust. In addition, the results of trial sequential analysis showed that evidences of our results are sufficient to reach concrete conclusions. Conclusions In conclusion, our meta-analysis found significant increased CVD risk is associated with rs266729 and rs2241766, but not associated with rs1501299. Electronic supplementary material The online version of this article (10.1186/s12944-018-0767-8) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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