Dermal exposure to the UV filter benzophenone-3 during early pregnancy affects fetal growth and sex ratio of the progeny in mice

Autor: Horacio A. Rodríguez, Anne Schumacher, Nicole Meyer, Maria Laura Zenclussen, Ana Claudia Zenclussen, Carla Mariela Teglia, María J. Culzoni, Clarisa Guillermina Santamaria
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
Amniotic fluid
Offspring
Placenta
Health
Toxicology and Mutagenesis
Intrauterine growth restriction
Gestational Age
Development
010501 environmental sciences
Administration
Cutaneous
Toxicology
Risk Assessment
01 natural sciences
Ciencias Biológicas
Fetal Development
Andrology
Benzophenones
03 medical and health sciences
Benzophenone-3
Pregnancy
medicine
Animals
Sex Ratio
Maternal-Fetal Exchange
0105 earth and related environmental sciences
Mice
Inbred BALB C
Fetus
Fetal Growth Retardation
business.industry
General Medicine
Amniotic Fluid
medicine.disease
Placentation
Mice
Inbred C57BL
030104 developmental biology
medicine.anatomical_structure
Maternal Exposure
Gestation
Female
Biología Reproductiva
business
Sex ratio
Sunscreening Agents
CIENCIAS NATURALES Y EXACTAS
Zdroj: Archives of Toxicology. 94:2847-2859
ISSN: 1432-0738
0340-5761
DOI: 10.1007/s00204-020-02776-5
Popis: The aim of this study was to analyze whether dermal exposure to benzophenone 3 (BP-3) during pregnancy affects criticalparameters of pregnancy, and whether this exposure may affect the outcome of a second pregnancy in mice. Pregnant micewere exposed to 50-mg BP-3/kg body weight/day or olive oil (vehicle) from gestation day (gd) 0 to gd6 by dermal exposure.High-frequency ultrasound imaging was used to follow up fetal and placental growth in vivo. Blood flow parameters inuterine and umbilical arteries were analyzed by Doppler measurements. Mice were killed at gd5, gd10, and gd14 on the firstpregnancy, and at gd10 and 14 on the second pregnancy. The weight of the first and second progenies was recorded, and sexratio was analyzed. BP-3 levels were analyzed in serum and amniotic fluid. BP-3 reduced the fetal weight at gd14 and fetoplacentaindex of first pregnancy, with 16.13% of fetuses under the 5th percentile; arteria uterina parameters showed alteredpattern at gd10. BP-3 was detected in serum 4 h after the exposure at gd6, and in amniotic fluid at gd14. Offspring weightof first progeny was lower in BP-3 group. Placenta weights of BP-3 group were decreased in second pregnancy. First andsecond progenies of mothers exposed to BP-3 showed a higher percentage of females (female sex ratio). Dermal exposureto low dose of BP-3 during early pregnancy resulted in an intrauterine growth restriction (IUGR) phenotype, disturbed sexratio and alterations in the growth curve of the offspring in mouse model. Fil: Santamaría, Clarisa Guillermina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina Fil: Meyer, Nicole. Otto-von-Guericke-Universität Magdeburg; Alemania Fil: Schumacher, Anne. Otto-von-Guericke-Universität Magdeburg; Alemania Fil: Zenclussen, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina Fil: Teglia, Carla Mariela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina Fil: Culzoni, Maria Julia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Química. Cátedra de Química Analítica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Zenclussen, Ana Claudia. Otto-von-Guericke-Universität Magdeburg; Alemania Fil: Rodriguez, Horacio Adolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina
Databáze: OpenAIRE
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