Genetic interaction between placental growth factor and vascular endothelial growth factor A in psoriasis

Autor: I. D. Kamaly‐Asl, Philip Laws, Helen S. Young, P. Pemberton, Christopher E.M. Griffiths
Rok vydání: 2019
Předmět:
Adult
Male
Vascular Endothelial Growth Factor A
Placental growth factor
endocrine system
medicine.medical_specialty
Genotype
Genotyping Techniques
Angiogenesis
Single-nucleotide polymorphism
Dermatology
Polymorphism
Single Nucleotide
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
Internal medicine
Psoriasis
medicine
Humans
Genetic Predisposition to Disease
Allele
Aged
Placenta Growth Factor
business.industry
Case-control study
Original Articles
Middle Aged
respiratory system
medicine.disease
Vascular endothelial growth factor A
Endocrinology
Case-Control Studies
030220 oncology & carcinogenesis
Original Article
Angiogenesis Inducing Agents
Female
lipids (amino acids
peptides
and proteins)
business
Biomarkers
hormones
hormone substitutes
and hormone antagonists
Zdroj: Clinical and Experimental Dermatology
Young, H S, Kamaly-asl, I D, Laws, P M, Pemberton, P & Griffiths, C E M 2019, ' Genetic interaction between placental growth factor and vascular endothelial growth factor A in psoriasis ', Clinical and Experimental Dermatology . https://doi.org/10.1111/ced.14102
ISSN: 1365-2230
0307-6938
DOI: 10.1111/ced.14102
Popis: Summary Background Expression of vascular endothelial growth factor A (VEGFA) is increased in chronic inflammatory skin diseases, including psoriasis, and loci for two VEGFA single nucleotide polymorphisms are associated with early‐onset psoriasis (presenting before the age of 40 years). Studies have suggested that expression of placenta growth factor (PGF) is also upregulated in cutaneous inflammation and that VEGFA‐mediated angiogenesis may be dependent on the simultaneous presence of PGF within the skin. Aim To elucidate the biological importance of PGF in psoriasis. Methods We investigated whether two commonly occurring PGF polymorphisms were associated with early‐onset psoriasis and the genetic interaction between VEGFA and PGF in psoriasis. Results We observed a significant (P = 0.04) association between rs2268614 TT and rs2268615 AA genotypes of PGF and early‐onset psoriasis. In addition, genetic complement, comprising the PGF rs2268615 AA genotype and the VEGFA −460 (rs833061) T allele, was significantly associated with the development of early‐onset psoriasis (P
Databáze: OpenAIRE
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