Glucagon-like Peptide-1 (7-37) Augments Insulin-Mediated Glucose Uptake in Elderly Patients With Diabetes
| Autor: | Raymond A. Pederson, Graydon S. Meneilly, Ronald L. Gingerich, Christopher H.S. McIntosh, Dariush Elahi, Josephine M. Egan, Joel F. Habener |
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| Rok vydání: | 2001 |
| Předmět: |
Blood Glucose
endocrine system Aging medicine.medical_specialty Glucose uptake medicine.medical_treatment Glucagon-Like Peptides Biological Transport Active Type 2 diabetes Glucagon chemistry.chemical_compound Glucagon-Like Peptide 1 Internal medicine Hyperinsulinemia medicine Humans Insulin Aged C-Peptide business.industry C-peptide Glucose clamp technique medicine.disease Glucagon-like peptide-1 Peptide Fragments Glucose Endocrinology Diabetes Mellitus Type 2 chemistry Glucose Clamp Technique Geriatrics and Gerontology Peptides business |
| Zdroj: | The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 56:M681-M685 |
| ISSN: | 1758-535X 1079-5006 |
| DOI: | 10.1093/gerona/56.11.m681 |
| Popis: | BACKGROUND Glucagon-like peptide-1 (GLP-1) is an intestinal insulinotropic hormone that augments glucose-induced insulin secretion in patients with type 2 diabetes. It has also been proposed that a substantial component of the glucose-lowering effects of GLP-1 occurs because this hormone enhances insulin-mediated glucose disposal. However, interpretations of the studies have been controversial. This study determines the effect of GLP-1 on insulin-mediated glucose disposal in elderly patients with type 2 diabetes. METHODS Studies were conducted on 8 elderly patients with type 2 diabetes (age range, 76 +/- 1 years; body mass index, 28 +/- 1 kg/m(2)). Each subject underwent two 180-minute euglycemic (insulin infusion rate, 40 mU/m(2)/min) insulin clamps in random order. Glucose production (Ra) and disposal (Rd) rates were measured using tritiated glucose methodology. In one study, glucose and insulin alone were infused. In the other study, a primed-continuous infusion of GLP-1 was administered at a final rate of 1.5 pmol x kg(-1) x min(-1) from 30 to 180 minutes. RESULTS Glucose values were similar between the control and GLP-1 infusion studies. 120- to 180-minute insulin values appeared to be higher during the GLP-1 infusion study (control, 795 +/- 63 pmol/l; GLP-1, 1140 +/- 275 pmol/l; p = not significant [NS]). The higher insulin values were largely due to 2 subjects who had substantial insulin responses to GLP-1 despite euglycemia and hyperinsulinemia. The 120- to 180-minute insulin values were similar in the other 6 subjects (control, 746 +/- 35 pmol/l; GLP-1, 781 +/- 41 pmol/l; p = NS). Basal (control, 2.08 +/- 0.05 mg/kg/min; GLP-1, 2.13 +/- 0.04 mg/kg/min; p = NS) and 120- to 180-minute (control, 0.50 +/- 0.18 mg/kg/min; GLP-1, 0.45 +/- 0.14 mg/kg/min; p = NS) Ra was similar between studies. The 120- to 180-minute Rd values were higher during the GLP-1 infusion studies (control, 4.73 +/- 0.39 mg/kg/min; GLP-1, 5.52 +/- 0.43 mg/kg/min; p |
| Databáze: | OpenAIRE |
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