Analysis of Ploidy and Proliferative Activity in Childhood Non-Hodgkin's Lymphoma (NHL) and Hodgkin'S Disease (HD)
| Autor: | Jillian R. Mann, T. J. Jones, F. Raafat, N. A. G. Coad, K. Smith, Kenneth Muir, S. E. Parkes |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Pathology medicine.diagnostic_test business.industry Aneuploidy General Medicine medicine.disease Pathology and Forensic Medicine Lymphoma Non-Hodgkin's lymphoma Immunophenotyping medicine.anatomical_structure immune system diseases hemic and lymphatic diseases Pediatrics Perinatology and Child Health Biopsy medicine Histopathology Stage (cooking) business B cell |
| Zdroj: | Pediatric Pathology & Laboratory Medicine. 17:893-902 |
| ISSN: | 1077-1042 |
| DOI: | 10.1080/15513819709168753 |
| Popis: | We have performed DNA analysis by means of fluorescence-activated cell cytometry on paraffin- embedded tissue from the diagnostic biopsy specimens in 40 cases of non-Hodgkin's lymphoma (NHL) and 25 of Hodgkin's disease (HD) and from 50 normal tonsils as controls. For HD cases, aneuploidy was found in 7 of 25 (28%), a higher proportion than in two previous studies of mainly adult patients. Diploid tumors showed S-phase fractions (SPFs) similar to those of controls. In the NHL cases aneuploidy was found in 12 of 40 (30%) with no significant association with site, stage, histopathology, immunophenotype, or prognosis. SPFs were highest in abdominal and chest primary sites but were not related to stage. Burkitt's lymphomas had the highest SPFs relative to lymphoblastic (P < .01) and centroblastic lymphomas (P < .05). Significantly higher SPFs were found, in B cell than in T cell tumors (P < .001). There was considerable heterogeneity for SPFs within each NHL subgroup. Survival was worse at 5 years for those wi... |
| Databáze: | OpenAIRE |
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