| Autor: |
Dongdong Li, Xiwei Yuan, Shiming Dong, Zaid AL‐Dhamin, Jinghua Du, Na Fu, Yuemin Nan |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Acta physiologica (Oxford, England). |
| ISSN: |
1748-1716 |
| Popis: |
Nonalcoholic steatohepatitis (NASH) is a severe form of nonalcoholic fatty liver disease (NAFLD) and lacks effective treatment options. Heme oxygenase-1 (HO-1) is a critical defense against oxidative stress and inflammation in the liver injury. This study aims to investigate the protective role and underlying mechanisms of HO-1 in NASH pathogenesis.The hepatocyte-specific HO-1 knockout (HO-1Hepatocyte-specific HO-1HO-1 attenuates diet-induced steatohepatitis by preventing mitochondrial dysfunction, indicating that HO-1 may constitute a potential therapeutic target for NASH. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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