Biomarkers of exposure and effect in a working population exposed to lead, manganese and arsenic
| Autor: | Madalena Cota, Maria Luísa Mateus, Vanda Andrade, Ana Paula Marreilha dos Santos, Daniela C Serrazina, Michael Aschner |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male inorganic chemicals 0301 basic medicine Health Toxicology and Mutagenesis chemistry.chemical_element Heme Manganese 010501 environmental sciences Toxicology 01 natural sciences Mining Arsenic Young Adult 03 medical and health sciences Lead (geology) Occupational Exposure Animals Humans Medicine Working population Adverse effect 0105 earth and related environmental sciences Portugal business.industry Middle Aged Rats 030104 developmental biology Lead chemistry Environmental chemistry Occupational exposure business Biomarkers Environmental Monitoring |
| Zdroj: | Journal of Toxicology and Environmental Health, Part A. 81:983-997 |
| ISSN: | 1087-2620 1528-7394 |
| Popis: | Lead (Pb), manganese (Mn) and arsenic (As) are among the major toxicants in mining environments. Miners are commonly and repeatedly exposed to this toxic mixture. Some adverse effects may appear at concentrations below environmental quality guidelines for individual mixture components. Further, Pb, Mn, and As induce common adverse outcomes, such as interferences in the cholinergic system and heme synthesis. It is thus vital to monitor miners through biomarkers (BM), such that subclinical effects may be identified at an early stage. The main objectives of this study were to evaluate the exposure of a mining population to these three metals and determine alterations in cholinergic and heme synthesis parameters. Blood and urine samples of workers (n = 60) were obtained from a Portuguese mining industry and compared with a control population (n = 80). The levels of the metals were determined in biological samples, as well as urinary heme precursor levels, delta aminolevulinic acid (ALA) and porphyrins, and blood acetylcholinesterase (AChE) activity. The miners exhibited significantly higher values of Pb and As in blood and urine compared to control. In the case of Mn near or slightly higher than limit values were found. Our data show that heme precursors may be used simultaneously with metal levels as BMs for multiple metal exposures on an individual basis, resulting in 94.3% and 95.7% accuracy, respectively, in blood and urine, for subjects correctly identified with respect to occupation. This study also revealed that biological monitoring of this working population regarding metal body burden and heme precursor accumulation is advisable. |
| Databáze: | OpenAIRE |
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