Role of anterior piriform cortex in the acquisition of conditioned flavour preference
| Autor: | S. Risco, Cristina Mediavilla, Mar Martín-Signes |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Infralimbic cortex Flavour Piriform Cortex Biology Nucleus accumbens Choice Behavior Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Piriform cortex Conditioning Psychological medicine Avoidance Learning Premovement neuronal activity Animals Fos immunohistochemistry Rats Wistar Saccharin Multidisciplinary Body Weight 030104 developmental biology medicine.anatomical_structure chemistry Taste Lithium Chloride Neuroscience Proto-Oncogene Proteins c-fos 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Flavour aversion learning (FAL) and conditioned flavour preference (CFP) facilitate animal survival and play a major role in food selection, but the neurobiological mechanisms involved are not completely understood. Neuroanatomical bases of CFP were examined by using Fos immunohistochemistry to record neuronal activity. Rats were trained over eight alternating one-bottle sessions to acquire a CFP induced by pairing a flavour with saccharin (grape was CS+ in Group 1; cherry in Group 2; in Group 3, grape/cherry in half of animals; Group 4, grape/cherry in water). Animals were offered the grape flavour on the day immediately after the training and their brains were processed for c-Fos. Neurons evidencing Fos-like immunoreactivity were counted in the infralimbic cortex, nucleus accumbens core, and anterior piriform cortex (aPC). Analysis showed a significantly larger number of activated cells after learning in the aPC alone, suggesting that the learning process might have produced a change in this cortical region. Ibotenic lesions in the aPC blocked flavour-taste preference but did not interrupt flavour-toxin FAL by LiCl. These data suggest that aPC cells may be involved in the formation of flavour preferences and that the integrity of this region may be specifically necessary for the acquisition of a CFP. |
| Databáze: | OpenAIRE |
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