Laccase-catalyzed derivatization of 6-aminopenicillanic, 7-aminocephalosporanic and 7-aminodesacetoxycephalosporanic acid
| Autor: | Ulrike Lindequist, Sabine Witt, Annett Mikolasch, Elke Hammer |
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| Rok vydání: | 2020 |
| Předmět: |
lcsh:Biotechnology
lcsh:QR1-502 Biophysics 010402 general chemistry 01 natural sciences Applied Microbiology and Biotechnology lcsh:Microbiology Catalysis chemistry.chemical_compound Trametes Biotransformation lcsh:TP248.13-248.65 Organic chemistry Derivatization Amination Laccase biology 010405 organic chemistry biology.organism_classification 0104 chemical sciences ß-lactam antibiotics chemistry Original Article Oxidative coupling of methane Antibacterial activity |
| Zdroj: | AMB Express AMB Express, Vol 10, Iss 1, Pp 1-7 (2020) |
| ISSN: | 2191-0855 |
| DOI: | 10.1186/s13568-020-01117-0 |
| Popis: | Trametes spec. laccase (EC 1.10.3.2.) mediates the oxidative coupling of 6-aminopenicillanic, 7-aminocephalosporanic, and 7-aminodesacetoxycephalosporanic acid with 2,5-dihydroxybenzoic acid derivatives to form new penicillin and cephalosporin structures, respectively. The heteromolecular hybrid dimers are formed by nuclear amination of the p-hydroquinones with the primary amines and inhibited in vitro the growth of Staphylococcus species, including some multidrug-resistant strains. |
| Databáze: | OpenAIRE |
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