Impulse oscillometry measurement of distal airways obstruction in depleted uranium-exposed Gulf War veterans
| Autor: | Joanna M. Gaitens, Ashley H. Barnes, Patricia Gucer, Melissa A. McDiarmid, Stella E. Hines, Marc Oliver, Clayton H. Brown, Marian Condon |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
inorganic chemicals Spirometry medicine.medical_specialty Respiratory Tract Diseases Vital Capacity Gulf war complex mixtures Pulmonary function testing Cohort Studies 03 medical and health sciences 0302 clinical medicine Forced Expiratory Volume Occupational Exposure Oscillometry Internal medicine Depleted uranium medicine Humans Bronchitis Lung health care economics and organizations Veterans medicine.diagnostic_test business.industry technology industry and agriculture Public Health Environmental and Occupational Health Middle Aged 030210 environmental & occupational health Asthma humanities Gulf War Respiratory Function Tests Dyspnea Impulse Oscillometry medicine.anatomical_structure Cough Pulmonary Emphysema 030228 respiratory system Cohort Cardiology Uranium business |
| Zdroj: | American Journal of Industrial Medicine. 61:308-316 |
| ISSN: | 0271-3586 |
| DOI: | 10.1002/ajim.22816 |
| Popis: | INTRODUCTION A cohort of Gulf War I veterans who sustained exposure to depleted uranium undergoes biennial surveillance for potential uranium-related health effects. We performed impulse oscillometry and hypothesized that veterans with higher uranium body burdens would have more obstructive abnormalities than those with lower burdens. METHODS We compared pulmonary function of veterans in high versus low urine uranium groups by evaluating spirometry and oscillometry values. RESULTS Overall mean spirometry and oscillometry resistance values fell within the normal ranges. There were no significant differences between the high and low uranium groups for any parameters. However, more veterans were classified as having obstruction by oscillometry (42%) than spirometry (8%). CONCLUSIONS While oscillometry identified more veterans as obstructed, obstruction was not uranium-related. However, the added sensitivity of this method implies a benefit in wider surveillance of exposed cohorts and holds promise in identifying abnormalities in areas of the lung historically described as silent. |
| Databáze: | OpenAIRE |
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