Increased ubiquinone concentration after intracerebroventricularly-administered ubiquinol to selected rat brain regions
| Autor: | Martin Tkačov, L Lackovicova, Boris Mravec, Katarina Ondicova, Anna Gvozdjáková, Ram B. Singh, Jarmila Kucharská |
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| Rok vydání: | 2012 |
| Předmět: |
Ubiquinol
Ubiquinone Physiology Biophysics macromolecular substances Pharmacology Fight-or-flight response chemistry.chemical_compound medicine Animals Tissue Distribution Circadian rhythm Coenzyme Q10 Dose-Response Relationship Drug Brain food and beverages General Medicine Rat brain Rats Up-Regulation Bioavailability Dose–response relationship Infusions Intraventricular medicine.anatomical_structure chemistry Ventricle |
| Zdroj: | General physiology and biophysics. 31:469-473 |
| ISSN: | 1338-4325 |
| DOI: | 10.4149/gpb_2012_052 |
| Popis: | Brain coenzyme Q10 (CoQ10) concentration can influence the activity of several brain regions, including those which participate in the regulation of cardiovascular circadian rhythms, food intake, neuroendocrine stress response, activity and sleep regulation. However, the effect of supplemented ubiquinol (reduced CoQ) into brain regions is not known. This study determined baseline levels of ubiquinone (oxidized CoQ) in various rat brain regions and proved the bioavailability of the liposomal ubiquinol to selected brain regions after its administration into right brain ventricle. Our data indicate that administration of ubiquinol may create the basis for modulation of neuronal activities in specific brain regions. |
| Databáze: | OpenAIRE |
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