Suppression of gastric acid secretory and ulcerogenic effects of cysteamine in chronic antrectomized rat
| Autor: | Spina G, Glässer Au, Fox U |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Atropine
Male medicine.medical_specialty Proglumide Cysteamine medicine.medical_treatment Gastric Acid chemistry.chemical_compound Internal medicine Pyloric Antrum medicine Animals Anesthesia Stomach Ulcer Cimetidine Antrum Gastrin Pharmacology Rats Inbred Strains Hydrogen-Ion Concentration Vagotomy Rats Endocrinology chemistry Gastric acid Histamine medicine.drug |
| Zdroj: | Pharmacological Research Communications. 14:679-686 |
| ISSN: | 0031-6989 |
| DOI: | 10.1016/s0031-6989(82)80026-x |
| Popis: | Summary The secretory and ulcerogenic effects of cysteamine were studied in normal and in chronically antrectomized rats. In agreement with the results obtained by other authors, cysteamine increased gastric acid secretion and induced duodenal ulcers. In our experiments hexamethonium, atropine and vagotomy had no effect on the hypersecretion induced by cysteamine. Acid hypersecretion was reduced in a dose-related manner by cimetidine and proglumide, the last claimed to be an antigastrin drug. Antrectomy completely blocked acid hypersecretion in both anaesthetized and conscious rats given cysteamine and protected conscious animals from cysteamine ulcer formation. It is worth stressing that chronically antrectomized rats were still able to respond to histamine infusion with acid hypersecretion. These results suggest that cysteamine may act mainly on the antrum probably inducing a release of gastrin. To confirm this hypothesis blood gastrin levels in normal and antrectomized rats during cysteamine treatment should be measured. |
| Databáze: | OpenAIRE |
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