Cardiac magnetic resonance features of left dominant arrhythmogenic cardiomyopathy: differential diagnosis with myocarditis

Autor: Cristina Basso, Antonio Dello Russo, Gianluca Pontone, Edoardo Conte, Saima Mushtaq, Giulia Vettor, Daniele Andreini, Stefania Rizzo, Patrizia Carità, Elena Sommariva, Michela Casella, Flavia Nicoli, Claudio Tondo, Mauro Pepi, Alessio Gasperetti, Valentina Catto
Rok vydání: 2021
Předmět:
Zdroj: The International Journal of Cardiovascular Imaging. 38:397-405
ISSN: 1573-0743
1569-5794
Popis: Cardiac magnetic resonance (CMR) findings suggesting a suspected left-dominant arrhythmogenic cardiomyopathy (LDAC) may be difficult to distinguish from those related to previous myocarditis; however, especially in patients with ventricular arrhythmias (VA) with ECG morphology consistent with a left ventricle (LV) origin differential diagnosis is fundamental. Aim of the study was to identify potential imaging features at CMR specific for LDAC diagnosis. Between January 2011 and December 2019, we enrolled 15 consecutive stable patients with a recent diagnosis of significant VA and ECG morphology consistent with a LV origin, detection of potential LV arrhythmic substrate at CMR and undergoing a clinically-indicated LV endomyocardial biopsy showing tissue abnormalities consistent with the diagnosis of LDAC. From the same CMR-endomyocardial biopsy registry, a second group of 30 consecutive patients who underwent CMR and biopsy with a histological diagnosis of previous myocarditis were identified. (1) Subepicardial LGE at the level of the posterolateral wall of the LV was detected in 13 cases of LDAC vs. 21 cases of myocarditis; (2) fat infiltration, and particularly subepicardial posterolateral fat infiltration, was found in almost all LDAC patients vs. one myocarditis only (p
Databáze: OpenAIRE
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