Kostchyienones A and B, new antiplasmodial and cytotoxicity of limonoids from the roots of Pseudocedrela kotschyi (Schweinf.) Harms
| Autor: | Achyut Adhikari, Yves Oscar Ditchou Nganso, Joel T. Dameue, Brussine N.K. Wakeu, Mehreen Lateef, Lazare Sidjui Sidjui, Muhammad Ali, Gabriel N. Folefoc, Pierre Mkounga, Rufin M.K. Toghueo |
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| Rok vydání: | 2017 |
| Předmět: |
Limonins
Pseudocedrela Traditional medicine biology Plant Extracts 010405 organic chemistry Chemistry Plasmodium falciparum Pseudocedrela kotschyi Antiprotozoal Agents biology.organism_classification Plant Roots 01 natural sciences General Biochemistry Genetics and Molecular Biology 0104 chemical sciences 010404 medicinal & biomolecular chemistry Natural source Ic50 values Meliaceae Cytotoxicity IC50 |
| Zdroj: | Zeitschrift für Naturforschung C. 73:153-160 |
| ISSN: | 1865-7125 0939-5075 |
| Popis: | Two new limonoids, kostchyienones A (1) and B (2), along with 12 known compounds 3–14 were isolated from the roots of Pseudocedrela kostchyi. Compound (7) was isolated for the first time from a natural source. Their structures were elucidated on the basis of spectroscopic evidence. Compounds 1–6 and 13–14 gave IC50 values ranging from 0.75 to 5.62 μg/mL for antiplasmodial activity against chloroquine-sensitive (Pf3D7) and chloroquine-resistant (PfINDO) strains of Plasmodium falciparum. Compound 5 showed moderate potential cytotoxicity against the HEK239T cell line with an IC50 value of 22.2±0.89 μg/mL. The antiplasmodial efficacy of the isolated compounds supports the medicinal value of this plant and its potential to provide novel antimalarial drugs. |
| Databáze: | OpenAIRE |
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