Homocysteine and other markers of cardiovascular risk during a manic episode in patients with bipolar disorder
| Autor: | Angela T. S. Wyse, Fabria Chiarani, Angela Sitta, Sérgio Carlos Eduardo Pinto Machado, Flávio Kapczinski, Keila Maria Mendes Ceresér, Carmen Regla Vargas, Maurício Kunz, Leonardo Ludwig Paim, Juliana Tramontina |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Homocysteine Gastroenterology Body Mass Index chemistry.chemical_compound Risk Factors cardiovascular disease lcsh:Psychiatry Prospective Studies Prospective cohort study Creatine Kinase bipolar disorder biology Middle Aged Diagnóstico [Doenças cardiovasculares] Psychiatry and Mental health Vitamin B 12 C-Reactive Protein Cardiovascular Diseases Ferritinas Female medicine.symptom Mania Adult medicine.medical_specialty Homocisteína lcsh:RC435-571 Folic Acid Internal medicine mental disorders medicine Humans Vitamin B12 Bipolar disorder Aged business.industry ferritin Case-control study Transtorno bipolar medicine.disease Surgery chemistry Case-Control Studies Ferritins biology.protein Creatine kinase business Body mass index Biomarkers |
| Zdroj: | Revista Brasileira de Psiquiatria, Volume: 35, Issue: 2, Pages: 157-160, Published: JUN 2013 Brazilian Journal of Psychiatry, Vol 35, Iss 2, Pp 157-160 (2013) Brazilian Journal of Psychiatry v.35 n.2 2013 Brazilian Journal of Psychiatry (São Paulo. 1999. Online) Associação Brasileira de Psiquiatria (ABP) instacron:ABP Repositório Institucional da UFRGS Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
| Popis: | Objective: To evaluate serum levels of different biomarkers associated with cardiovascular disease in patients with bipolar disorder (BD). Patients were prospectively evaluated in two separate instances: during acute mania and after remission of manic symptoms. All measurements were compared with those of healthy controls. Methods: The study included 30 patients with BD and 30 healthy controls, matched for gender and age. Biochemical parameters evaluated included homocysteine (Hcy), folic acid, vitamin B12, ferritin, creatine kinase (CK) and C-reactive protein (CRP). Results: Hcy levels were significantly higher in the BD patients, both during mania and after achieving euthymia. When Hcy was adjusted for body mass index, there was no significant difference between patients and controls. Ferritin was the only marker that showed a significant decrease during mania when compared to both euthymic patients and controls. There were no significant differences for folate, vitamin B12, CK and CRP. Conclusions: These findings do not show an association between alterations of markers of cardiovascular risk during manic episodes. Further studies are necessary to determine factors and mechanisms associated with cardiovascular risk in patients with BD. |
| Databáze: | OpenAIRE |
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