Mycoplasma genitalium prevalence and macrolide resistance-associated mutations and coinfection with Chlamydia trachomatis in Southern Jutland, Denmark
| Autor: | Rasmus Desdorf, Niles Moller Andersen, Ming Chen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Chlamydia Infections/microbiology Denmark Mycoplasma genitalium/drug effects Chlamydia trachomatis Mycoplasma genitalium Gene mutation medicine.disease_cause urologic and male genital diseases Prevalence Immunology and Allergy Medicine macrolide resistance mutations Mycoplasma Infections/microbiology High prevalence biology Coinfection Drug Resistance Bacterial/genetics General Medicine Macrolides/pharmacology Middle Aged female genital diseases and pregnancy complications Anti-Bacterial Agents Coinfection/microbiology Macrolide resistance Female Macrolides Microbiology (medical) Adult Adolescent Pathology and Forensic Medicine Anti-Bacterial Agents/pharmacology Young Adult Chlamydia trachomatis/isolation & purification 23S ribosomal RNA Drug Resistance Bacterial Humans Mycoplasma Infections Aged business.industry Chlamydia Infections medicine.disease biology.organism_classification bacterial infections and mycoses Virology coinfection Mutation Neisseria gonorrhoeae business |
| Zdroj: | Desdorf, R, Andersen, N M & Chen, M 2021, ' Mycoplasma genitalium prevalence and macrolide resistance-associated mutations and coinfection with Chlamydia trachomatis in Southern Jutland, Denmark ', A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica (Online), vol. 129, no. 12, pp. 706-710 . https://doi.org/10.1111/apm.13174 |
| DOI: | 10.1111/apm.13174 |
| Popis: | This study aims to investigate prevalence of Mycoplasma genitalium and macrolide resistance-associated mutations and coinfection with other sexually transmitted bacteria in Southern Jutland, Denmark, where this information is very limited. Urinary samples from patients suspected of sexually transmitted bacterial infections collected at primary healthcare facilities in Southern Jutland are routinely tested for Chlamydia trachomatis and Neisseria gonorrhoeae. 601 of these samples were analysed with SpeeDx MG+23S reagents, which can detect M. genitalium and macrolide resistance-mediating mutations in the 23S rRNA gene. Moreover, 147 C. trachomatis positive urinary samples from routine test were also analysed with the PCR assay to detect M. genitalium. 72 out of 601 samples were detected positive for C. trachomatis (12%), five samples (0.83%) positive for N. gonorrhoeae and 25 samples positive for M. genitalium (4.2%). 14 of the 25 M. genitalium samples were detected having 23S rRNA gene mutations associated with macrolide resistance (56%). 25 of 147 C. trachomatis positive samples were tested positive for M. genitalium (17%) and two of them were positive for M. genitalium and N. gonorrhoeae (1.4%). The high prevalence of M. genitalium and macrolide resistance-associated mutation and the coinfection with C. trachomatis in the region suggesting that M. genitalium testing should be included in routine sexually transmitted infection screening. |
| Databáze: | OpenAIRE |
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