Lymphomatoid granulomatosis--a report on four cases: evidence for B phenotype of the tumoral cells
| Autor: | Françoise Berger, J.F. Cordier, Ph. Tanière, R. Loire, D. Vitrey, Françoise Thivolet-Béjui, S. Isaac |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Epstein-Barr Virus Infections Pathology medicine.medical_specialty Lung Neoplasms Lymphomatoid granulomatosis In situ hybridization Biology medicine.disease_cause Herpesviridae Virus Immunoenzyme Techniques Antigens CD hemic and lymphatic diseases medicine Humans Lung In Situ Hybridization Histiocyte B-Lymphocytes Membrane Glycoproteins Lysosome-Associated Membrane Glycoproteins Lymphomatoid Granulomatosis Middle Aged medicine.disease Epstein–Barr virus Phenotype Epstein-Barr Virus Nuclear Antigens Membrane protein Female |
| Zdroj: | European Respiratory Journal. 12:102-106 |
| ISSN: | 1399-3003 0903-1936 |
| DOI: | 10.1183/09031936.98.12010102 |
| Popis: | Four cases of lymphomatoid granulomatosis are reported, three of them involving the lung. Histological features included a true angiocentric and angiodestructive polymorphic cellular proliferation. This included histiocytes, plasma cells, many reactive T-cells and rare large, atypical cells which were of the B phenotype. Epstein-Barr virus was detected in the atypical cells by in situ hybridization in three cases, with expression of both latent membrane proteins (LMP)-1 and Epstein-Barr nuclear antigen-2 in two cases and expression of only LMP-1 in the third case. Expression of both of these proteins suggests a defect in the T-cell-mediated immunity and that Epstein-Barr virus is not only a silent passenger but may also be involved in the pathogenesis of the disease. This could have implications for therapy. |
| Databáze: | OpenAIRE |
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