LATS2 inhibits cell proliferation and metastasis through the Hippo signaling pathway in glioma
Autor: | Chengyong Guo, Jipeng Yang, Bo Fan, Chaohui Liang, Xin Liu, Hongchao Hu |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Male Cancer Research Cell cell migration and invasion 0302 clinical medicine glioma Phosphorylation RNA Small Interfering Child Kinase Chemistry Brain Neoplasms Brain General Medicine Articles Cell cycle Middle Aged LATS2 medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Gene Knockdown Techniques Disease Progression Female Signal transduction Signal Transduction Adult Adolescent Down-Regulation Protein Serine-Threonine Kinases 03 medical and health sciences Young Adult Downregulation and upregulation Glioma Cell Line Tumor medicine YAP/TAZ Humans Hippo Signaling Pathway Adaptor Proteins Signal Transducing Aged Cell Proliferation Hippo signaling pathway Cell growth Tumor Suppressor Proteins YAP-Signaling Proteins medicine.disease Phosphoproteins 030104 developmental biology Cancer research Acyltransferases Transcription Factors |
Zdroj: | Oncology Reports |
ISSN: | 1791-2431 1021-335X |
Popis: | As a core kinase in the Hippo pathway, large tumor suppressor kinase 2 (LATS2) regulates cell proliferation, migration and invasion through numerous signaling pathways. However, its functions on cell proliferation, migration and invasion in glioma have yet to be elucidated. The present study revealed that LATS2 was downregulated in glioma tissues and cells, as determined by reverse transcription‑quantitative polymerase chain reaction and immunohistochemistry. In addition, Cell Counting Kit‑8, scratch wound healing and Transwell assays revealed that overexpression of LATS2 in U‑372 MG cells inhibited cell proliferation, migration and invasion. Furthermore, western blot analysis indicated that the expression levels of phosphorylated (p)‑yes‑associated protein and p‑tafazzin were increased in cells with LATS2 overexpression. These results indicated that LATS2 is a potential tumor suppressor, and downregulation of LATS2 in glioma may contribute to cancer progression. |
Databáze: | OpenAIRE |
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