LATS2 inhibits cell proliferation and metastasis through the Hippo signaling pathway in glioma

Autor: Chengyong Guo, Jipeng Yang, Bo Fan, Chaohui Liang, Xin Liu, Hongchao Hu
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Male
Cancer Research
Cell
cell migration and invasion
0302 clinical medicine
glioma
Phosphorylation
RNA
Small Interfering
Child
Kinase
Chemistry
Brain Neoplasms
Brain
General Medicine
Articles
Cell cycle
Middle Aged
LATS2
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Gene Knockdown Techniques
Disease Progression
Female
Signal transduction
Signal Transduction
Adult
Adolescent
Down-Regulation
Protein Serine-Threonine Kinases
03 medical and health sciences
Young Adult
Downregulation and upregulation
Glioma
Cell Line
Tumor
medicine
YAP/TAZ
Humans
Hippo Signaling Pathway
Adaptor Proteins
Signal Transducing
Aged
Cell Proliferation
Hippo signaling pathway
Cell growth
Tumor Suppressor Proteins
YAP-Signaling Proteins
medicine.disease
Phosphoproteins
030104 developmental biology
Cancer research
Acyltransferases
Transcription Factors
Zdroj: Oncology Reports
ISSN: 1791-2431
1021-335X
Popis: As a core kinase in the Hippo pathway, large tumor suppressor kinase 2 (LATS2) regulates cell proliferation, migration and invasion through numerous signaling pathways. However, its functions on cell proliferation, migration and invasion in glioma have yet to be elucidated. The present study revealed that LATS2 was downregulated in glioma tissues and cells, as determined by reverse transcription‑quantitative polymerase chain reaction and immunohistochemistry. In addition, Cell Counting Kit‑8, scratch wound healing and Transwell assays revealed that overexpression of LATS2 in U‑372 MG cells inhibited cell proliferation, migration and invasion. Furthermore, western blot analysis indicated that the expression levels of phosphorylated (p)‑yes‑associated protein and p‑tafazzin were increased in cells with LATS2 overexpression. These results indicated that LATS2 is a potential tumor suppressor, and downregulation of LATS2 in glioma may contribute to cancer progression.
Databáze: OpenAIRE
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