Effects of cold exposure and shear stress on endothelial nitric oxide synthase activation
| Autor: | Tateki Sumii, Naoto Kawasaki, Kamariah binti Md Isa, Keiichi Ueyama, Susumu Kudo |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Nitric Oxide Synthase Type III
Biophysics Vasodilation Biochemistry Nitric oxide Enzyme activator chemistry.chemical_compound Enos medicine Shear stress Animals Humans Molecular Biology Cells Cultured biology Cell Biology biology.organism_classification Cold Temperature Enzyme Activation medicine.anatomical_structure chemistry Cattle Endothelium Vascular Stress Mechanical medicine.symptom Shear Strength Vasoconstriction Blood vessel |
| Zdroj: | Biochemical and Biophysical Research Communications. 412:318-322 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/j.bbrc.2011.07.092 |
| Popis: | Endothelial nitric oxide synthase (eNOS) is the primary enzyme that produces nitric oxide (NO), which plays an important role in blood vessel relaxation. eNOS activation is stimulated by various mechanical forces, such as shear stress. Several studies have shown that local cooling of the human finger causes strong vasoconstriction, followed after several minutes by cold-induced vasodilation (CIVD). However, the role played by endothelial cells (ECs) in blood vessel regulation in respond to cold temperatures is not fully understood. In this study, we found that low temperature alone does not significantly increase or decrease eNOS activation in ECs. We further found that the combination of shear stress with temperature change leads to a significant increase in eNOS activation at 37°C and 28°C, and a decrease at 4°C. These results show that ECs play an important role in blood vessel regulation under shear stress and low temperature. |
| Databáze: | OpenAIRE |
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