Radiological and clinical features of screening-detected pulmonary invasive mucinous adenocarcinoma
| Autor: | In Kyu Park, Kwon Joong Na, Samina Park, So Young Bae, Chang Hyun Kang, Young Tae Kim, Dae Hyeon Kim |
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| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Lung Neoplasms Disease-free survival Thoracic Adenocarcinoma of Lung medicine Humans Stage (cooking) Lung Survival rate Pathological Neoplasm Staging Retrospective Studies Percutaneous needle biopsy AcademicSubjects/MED00920 business.industry Disease progression Nodule (medicine) Original Articles medicine.disease Adenocarcinoma Mucinous Early detection of cancer Radiological weapon Adenocarcinoma Surgery Radiology medicine.symptom Cardiology and Cardiovascular Medicine business Mucinous adenocarcinoma |
| Zdroj: | Interactive Cardiovascular and Thoracic Surgery |
| ISSN: | 1569-9285 |
| DOI: | 10.1093/icvts/ivab257 |
| Popis: | OBJECTIVES The current understanding of pulmonary invasive mucinous adenocarcinoma is largely based on studies of advanced stage patients and data about early-stage invasive mucinous adenocarcinoma are sparse. We evaluated the radiological and clinical features of screening-detected early-stage invasive mucinous adenocarcinoma (SD-IMA). METHODS Data from 91 patients who underwent surgical treatment for SD-IMA (≤3 cm) from 2013 to 2019 were reviewed retrospectively. Data on radiological characteristics, clinicopathological findings, recurrence and survival were obtained. Disease-free survival rate was analysed. RESULTS Radiologically, SD-IMAs presented as a pure ground-glass nodule (6.6%), part-solid nodule (38.5%) or solid (54.9%). Dominant locations were both lower lobes (74.7%) and peripheral area (93.4%). The sensitivity of percutaneous needle biopsy was 78.1% (25/32). Lobectomy was performed in 70 (76.9%) patients, and sublobar resection in 21 (23.1%) patients. Seventy-three (80.2%), 15 (16.5%) and 3 (3.3%) patients had pathological stage IA, IB and IIB or above, respectively. Seven patients developed recurrence, and 3 died due to disease progression. Pleural seeding developed exclusively in 2 patients who underwent needle biopsy. The 5-year disease-free survival rate was 89.4%. The disease-free survival rates at 5 years were 86.3% in the lobectomy group and 100% in the sublobar resection group. CONCLUSIONS SD-IMAs were mostly radiologically invasive nodules. SD-IMAs showed favourable prognosis after surgical treatment. Invasive mucinous adenocarcinoma (IMA), which accounts for 5% of pulmonary adenocarcinomas, has different characteristics than non-mucinous adenocarcinoma (NMA) in terms of histology, genetics and clinical features. |
| Databáze: | OpenAIRE |
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