Variation in predicted internal concentrations in relation to PBPK model complexity for rainbow trout
| Autor: | Vladimir Potemkin, Dominik Wondrousch, Gerrit Schüürmann, Elena Salmina, Ralph Kühne |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Physiologically based pharmacokinetic modelling Environmental Engineering Kinetics 010501 environmental sciences Models Biological 01 natural sciences 03 medical and health sciences Biotransformation Molecular descriptor Animals Environmental Chemistry Waste Management and Disposal 0105 earth and related environmental sciences Chemistry Chemical polarity Solvation Pollution 030104 developmental biology Oncorhynchus mykiss Environmental chemistry Environmental toxicology Polar Biological system Water Pollutants Chemical Environmental Monitoring |
| Zdroj: | Science of The Total Environment. 550:586-597 |
| ISSN: | 0048-9697 |
| DOI: | 10.1016/j.scitotenv.2016.01.107 |
| Popis: | The present study is motivated by the increasing demand to consider internal partitioning into tissues instead of exposure concentrations for the environmental toxicity assessment. To this end, physiologically based pharmacokinetic (PBPK) models can be applied. We evaluated the variation in accuracy of PBPK model outcomes depending on tissue constituents modeled as sorptive phases and chemical distribution tendencies addressed by molecular descriptors. The model performance was examined using data from 150 experiments for 28 chemicals collected from US EPA databases. The simplest PBPK model is based on the "Kow-lipid content" approach as being traditional for environmental toxicology. The most elaborated one considers five biological sorptive phases (polar and non-polar lipids, water, albumin and the remaining proteins) and makes use of LSER (linear solvation energy relationship) parameters to describe the compound partitioning behavior. The "Kow-lipid content"-based PBPK model shows more than one order of magnitude difference in predicted and measured values for 37% of the studied exposure experiments while for the most elaborated model this happens only for 7%. It is shown that further improvements could be achieved by introducing corrections for metabolic biotransformation and compound transmission hindrance through a cellular membrane. The analysis of the interface distribution tendencies shows that polar tissue constituents, namely water, polar lipids and proteins, play an important role in the accumulation behavior of polar compounds with H-bond donating functional groups. For compounds without H-bond donating fragments preferable accumulation phases are storage lipids and water depending on compound polarity. |
| Databáze: | OpenAIRE |
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