On-Demand Local Immunomodulation via Epigenetic Control of Macrophages Using an Inflammation-Responsive Hydrogel for Accelerated Wound Healing

Autor:	Hyerim Kim, Yunji Joo, Yun-Min Kook, Na Ly Tran, Sang-Heon Kim, Kangwon Lee, Seung Ja Oh
Rok vydání:	2022
Předmět:	Inflammation Wound Healing Surface Properties Macrophages Materials Testing Anticoagulants Humans Biocompatible Materials Dextrans Hydrogels General Materials Science Particle Size Cells Cultured
Zdroj:	ACS Applied Materials & Interfaces. 14:4931-4945
ISSN:	1944-8252 1944-8244
DOI:	10.1021/acsami.1c20394
Popis:	Effective resolution of inflammation contributes to favorable tissue regenerative therapeutic outcomes. However, fine coordination of local immunomodulation in a timely manner is limited because of the lack of strategies for controlling disease dynamics. We developed an inflammation-responsive hydrogel (IFRep gel) as an effective therapeutic strategy for on-demand epigenetic modulation against disease dynamics in wound healing. The IFRep gel is designed to control drug release by cathepsins according to the state of inflammation for active disease treatment. The gel loaded with an inhibitor of the epigenetic reader bromodomain (BRD)4 regulates the translocation of nuclear factor erythroid 2 to the nucleus, where it promotes antioxidant gene expression to reverse the inflammatory macrophage state
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c79d73d75fbdf2aea36807c25fb7b1 https://doi.org/10.1021/acsami.1c20394 Zobrazit plný text záznamu