No effect of age, gender and total intracranial volume on brainstem MR planimetric measurements
| Autor: | Eva Reiter, Anna Hussl, Stephanie Mangesius, Florian Krismer, Susanne Tagwercher, Philipp Mahlknecht, Elke R. Gizewski, Klaus Seppi, Werner Poewe, Michael Schocke, Christoph Müller, Lukas Lenhart |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Aging medicine.medical_specialty Parkinsonian disorders Population Diagnosis differential Midbrain 03 medical and health sciences Sex Factors 0302 clinical medicine Image Processing Computer-Assisted Humans Medicine Radiology Nuclear Medicine and imaging education Aged Neuroradiology Aged 80 and over education.field_of_study medicine.diagnostic_test business.industry Parkinsonism Age Factors Parkinson Disease Magnetic resonance imaging General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Pons 030104 developmental biology Superior cerebellar peduncle medicine.anatomical_structure Female Brainstem Radiology Neuro business 030217 neurology & neurosurgery Brain Stem |
| Zdroj: | European Radiology |
| ISSN: | 1432-1084 0938-7994 |
| DOI: | 10.1007/s00330-019-06504-1 |
| Popis: | Objectives MR planimetry of brainstem structures can be helpful for the discrimination of Parkinsonian syndromes. It has been suggested that ageing might influence brainstem MR measurements assessed by MR planimetry, while effects of gender and total intracranial volume (TIV) have not been assessed so far. The aim of this study was to evaluate age, gender and TIV effects on brainstem MR planimetric measures. Methods Brainstem MR planimetric measures of diameters (midbrain, pons, middle and superior cerebellar peduncle) and areas (pons and midbrain), the derived ratios, and the magnetic resonance Parkinsonism index (MRPI) were assessed on 1.5-T MR images in a large cohort of 97 healthy controls and analysed for the influence of age, gender and TIV with univariate and multivariate linear models. Results Neither gender nor age effects on planimetric measurements were observed in the population relevant for the differential diagnosis of neurodegenerative Parkinsonism, aged 50 to 80 years, except for single area-derived measurements, with gender effects on pontine area (p = 0.013) and age effects on midbrain area (p = 0.037). Results were similar upon inclusion of the TIV in the analyses. Conclusions There is no need to correct for age, gender or TIV when using brainstem-derived MR planimetric measurements in the differential diagnosis of neurodegenerative Parkinsonism. Key Points • There were no gender effects on single or combined imaging measurements of the brainstem in the population aged 50 to 80 years, the age range relevant for the differential diagnosis of neurodegenerative Parkinsonism (except for pontine area). • There were no age effects on single or combined imaging measurements of the brainstem in the population aged 50 to 80 years, the age range relevant for the differential diagnosis of neurodegenerative Parkinsonism (except for midbrain area). • There is no need for age- or gender-specific cut-offs for the relevant age group. |
| Databáze: | OpenAIRE |
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