The effect of 7-nitroindazole on the acquisition and expression of D-methamphetamine-induced place preference in rats
| Autor: | Jie Shi, Su-Min Li, Ji-Wang Zheng, Zhi-Bin Lin, Lin-Lin Yin |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
7-Nitroindazole Indazoles medicine.medical_treatment Pharmacology Nitric Oxide Choice Behavior Nitric oxide Methamphetamine Rats Sprague-Dawley chemistry.chemical_compound Reward Conditioning Psychological medicine Animals Drug Interactions Saline biology Chemistry Biological activity Conditioned place preference Rats Nitric oxide synthase Mechanism of action Anti-Anxiety Agents Anesthesia biology.protein medicine.symptom Nitric Oxide Synthase medicine.drug |
| Zdroj: | European journal of pharmacology. 435(2-3) |
| ISSN: | 0014-2999 |
| Popis: | The present study investigated the role of nitric oxide (NO) in the rewarding effects of D-methamphetamine using 7-nitroindazole, a potent inhibitor of neuronal nitric oxide synthase (nNOS), as determined by the conditioned place preference paradigm. Male Sprague-Dawley rats treated with D-methamphetamine (1 mg/kg) or saline every other day for 8 days (four drug and four saline sessions) developed marked place preference for the drug-paired side. The administration of 7-nitroindazole (12.5-50 mg/kg) 30 min prior to the exposure to D-methamphetamine dose-dependently attenuated the acquisition of D-methamphetamine-induced conditioned place preference. In addition, when it was acutely administered 30 min prior to the testing session of an already established D-methamphetamine-induced conditioned place preference, 7-nitroindazole (12.5-50 mg/kg) attenuated the expression of this conditioned response in a dose-dependent manner, while 7-nitroindazole (25 and 50 mg/kg) alone showed no place preference effects. These findings indicate that nitric oxide (NO) is involved in the rewarding properties of methamphetamine and suggest that selective nNOS inhibitors maybe useful in the management of methamphetamine abuse. |
| Databáze: | OpenAIRE |
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