Patients with acute on chronic liver failure display ‘sepsis-like’ immune paralysis

Autor: Daniel Vidacek, Siegfried Matern, Jens Bach, Eray Yagmur, Axel M. Gressner, Edmund Purucker, Andreas Geier, Dagmar Kunz, Elmar Siewert, Frank Lammert, Hermann E. Wasmuth, Annette Timmer-Stranghöner
Rok vydání: 2005
Předmět:
Zdroj: Journal of Hepatology. 42:195-201
ISSN: 0168-8278
DOI: 10.1016/j.jhep.2004.10.019
Popis: Cellular immune depression is linked to high mortality in sepsis, but has yet to be systematically analysed in liver cirrhosis. The aim of the present study was to directly compare functional immune parameters in patients with acute on chronic liver failure (ACLF), severe sepsis, and non-decompensated cirrhosis.Patients with ACLF (n=27) were investigated at admission to a medical ICU. Patients with stable liver cirrhosis (n=24) and severe sepsis (n=31) served as control groups. In all subjects, serum levels of IL-6 and IL-10, ex vivo production of TNF-alpha in a whole blood assay, and monocyte surface HLA-DR expression were determined.In patients with ACLF or sepsis, ex vivo TNF-alpha production and HLA-DR expression were severely decreased compared to subjects with stable cirrhosis (both P0.001). Contrary, IL-6 levels were highest in septic patients, followed by subjects with ACLF and cirrhotic patients (both P0.05). Immune dysfunction in ACLF was independent of aetiology of liver cirrhosis and associated with high mortality.Patients with ACLF and severe sepsis show a similar degree of cellular immune depression. The reduced cellular immune function in subjects with ACLF might contribute to the increased infectious morbidity of these patients and provide a rational basis for prevention strategies.
Databáze: OpenAIRE
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