FATE OF CHLORBUTOL DURING STORAGE IN POLYETHYLENE DROPPER CONTAINERS AND SIMULATED PATIENT USE
| Autor: | D G Holdsworth, Michael S. Roberts, Alan E. Polack |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Chlorobutanol
Pharmacology medicine.medical_specialty Chromatography Gas Materials science Chromatography Aqueous solution Drug Storage Temperature Sorption Chlorbutol Permeation Polyethylene Surgery chemistry.chemical_compound Drug Stability chemistry medicine Pharmacology (medical) Ophthalmic Solutions Polyethylenes Drug Packaging |
| Zdroj: | Journal of Clinical Pharmacy and Therapeutics. 9:29-39 |
| ISSN: | 1365-2710 0269-4727 |
| DOI: | 10.1111/j.1365-2710.1984.tb00916.x |
| Popis: | The disappearance of chlorbutol from aqueous solutions stored in polyethylene containers under various experimental and simulated patient use conditions is described. Chlorbutol is lost by sorption into the container wall, container insert and by permeation into the external environment. The extent of chlorbutol loss from solution and uptake by the container components is dependent on temperature, chlorbutol concentration and the closure used. Aqueous chlorbutol solutions stored in the polyethylene container evaluated have a predicted shelf-life (time for 10% loss) of about 4 months at 25 degrees C and 8 months at 20 degrees C. Negligible loss is found during simulated patient use over 1 month. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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