Hemibody irradiation (HBI) for metastatic bone pain in two histologically distinct groups of patients
| Autor: | Peter Hoskin, H.T. Ford, Clive Harmer |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Pain Bone Neoplasms Metastatic bone pain Gastroenterology Prostate cancer Internal medicine parasitic diseases Carcinoma medicine Methods Humans Radiology Nuclear Medicine and imaging Bone pain Pneumonitis Aged Retrospective Studies Aged 80 and over Hemibody irradiation business.industry Palliative Care Prostatic Neoplasms Middle Aged medicine.disease Bone marrow suppression Toxicity medicine.symptom business Multiple Myeloma |
| Zdroj: | Clinical oncology (Royal College of Radiologists (Great Britain)). 1(2) |
| ISSN: | 0936-6555 |
| Popis: | Fifty patients with hemibody irradiation (HBI) for metastatic bone pain have been reviewed. A total of 60 treatments were given (9 upper HBI, 31 lower HBI and 10 both upper and lower HBI). Seventeen patients had metastatic myeloma and 30 had metastatic prostatic carcinoma. The overall response rate was 83% with a 5% complete response rate. Response was seen within 24 hours in 25% of treatments and lasted until death in 74%. No difference in the response characteristics was seen between those patients with myeloma and those with prostatic carcinoma. Significant toxicity occurred in 60% of patients, predominantly gastrointestinal toxicity and bone marrow suppression. One case of fatal pneumonitis occurred. The possibility of maintaining these response rates but reducing toxicity using lower doses of HBI is discussed. |
| Databáze: | OpenAIRE |
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