Discovery of a tetrazole-based growth hormone secretagogue: 4-(hydroxybutyl)carbamic acid 2-{5-[1-(2-amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl ester (BMS-317180)

Autor:	Mujing Yan, Jeffrey A. Robl, Hongjian Zhang, Haixia Wang, Ramakrishna Seethala, Christa M. Musial, Bharat P. Patel, David A. Gordon, Terry R. Stouch, James J. Li, Kenneth E.J. Dickinson, Peter T. W. Cheng, Blake C. Beehler, Brian J. Murphy, Jun Li, Leah Giupponi, Shiwei Tao, Fucheng Qu, Gary J. Grover, Joseph A. Tino, Sam T. Chao, Mark A. Smith, William G. Humphreys, Neil Flynn, Dorothy Slusarchyk, William R. Ewing, Stephanie Y. Chen, Andres S. Hernandez, Stephen G. Swartz, Mark D. Schwinden, Paul G. Sleph, Scott A. Biller
Rok vydání:	2007
Předmět:	medicine.drug_class Peptidomimetic Stereochemistry education Administration Oral Biological Availability Tetrazoles Ether Carboxamide Chemical synthesis chemistry.chemical_compound Structure-Activity Relationship Carbamic acid Dogs Growth hormone secretagogue Drug Discovery medicine Animals Humans Tetrazole Human Growth Hormone Water Esters Rats stomatognathic diseases Macaca fascicularis chemistry Solubility Growth Hormone Molecular Medicine Secretagogue Carbamates hormones hormone substitutes and hormone antagonists
Zdroj:	Journal of medicinal chemistry. 50(24)
ISSN:	0022-2623
Popis:	A tetrazole-based peptidomimetic 2 (BMS-317180) was discovered as a human growth hormone secretagogue (GHS). Compound 2 is a potent, novel, orally effective GHS that shows an excellent safety profile in preclinical studies. The compound was advanced into clinical development.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1bb1f4e174b570de15ab83471826b78 https://pubmed.ncbi.nlm.nih.gov/17973363 Zobrazit plný text záznamu