ROS-boosted photodynamic therapy against metastatic melanoma by inhibiting the activity of antioxidase and oxygen-producing nano-dopants
| Autor: | Hanchun Yao, Weiran Ye, Qiaolei Wang, Shizhen Geng, Qianwen Yin, Jie Zhou, Rui Lou, Bin Du |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Skin Neoplasms Antioxidant medicine.medical_treatment Melanoma Experimental Metal Nanoparticles chemistry.chemical_element Photodynamic therapy Oxygen Mice 03 medical and health sciences 0302 clinical medicine medicine Animals Humans Photosensitizer Melanoma Titanium Pharmacology chemistry.chemical_classification Reactive oxygen species Dose-Response Relationship Drug biology Tumor hypoxia CD44 medicine.disease Xenograft Model Antitumor Assays Mice Inbred C57BL Oxidative Stress 030104 developmental biology Photochemotherapy chemistry 030220 oncology & carcinogenesis Cancer research biology.protein Female Gold Reactive Oxygen Species |
| Zdroj: | Pharmacological Research. 158:104885 |
| ISSN: | 1043-6618 |
| DOI: | 10.1016/j.phrs.2020.104885 |
| Popis: | The antioxidant effect weakens the ability of PDT to resist melanoma, and the hypoxic tumor environment further restricts the application of photosensitizers in tumors. Therefore, to enhance the ability of PDT to resist melanoma, we designed a sequential enhanced PDT theranostic platform (Au@MTM-HA). Firstly, the nanotherapeutic platform uses TiO2 as a photosensitizer, which is doped with MnO2 to form a mesoporous MTM. The MTM can continuously provide oxygen, thereby increasing the level of reactive oxygen species (ROS) and reducing the metastatic effect by alleviating tumor hypoxia. Furthermore, the released Au25Sv9 could inhibit the activity of antioxidant defense enzymes and reduce the scavenging of ROS and further enhance the PDT effect. Simultaneously, surface-modified HA could not only recognize CD44 receptor but also act as a sealing agent for carriers. Result: Au@MTM-HA could explosively produce a 3-fold higher ROS and improve the PDT effect. Therefore, this work may provide strong evidence for Au@MTM-HA as a new and promising PDT candidate for the treatment of metastatic melanoma. |
| Databáze: | OpenAIRE |
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