Antiproliferative Activity of a New Nitrosyl Iron Complex with Cysteamine in Human Tumor Cells In Vitro
| Autor: | I O Chikileva, Z S Smirnova, O S Zhukova, M. V. Kiselevskii |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Methyltransferase DNA Repair Cell Survival Cysteamine Iron Gene Expression Antineoplastic Agents Apoptosis General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Basal (phylogenetics) chemistry.chemical_compound 0302 clinical medicine Coordination Complexes Cell Line Tumor Cytotoxic T cell Humans DNA Modification Methylases Caspase Cell Proliferation biology Dose-Response Relationship Drug Tumor Suppressor Proteins General Medicine In vitro 030104 developmental biology DNA Repair Enzymes chemistry Biochemistry Cell culture A549 Cells Organ Specificity 030220 oncology & carcinogenesis biology.protein Cancer research Nitrogen Oxides K562 Cells |
| Zdroj: | Bulletin of experimental biology and medicine. 162(4) |
| ISSN: | 1573-8221 |
| Popis: | We studied cytotoxic activity of a new NO-releasing tetranitrosyl binuclear iron complex with cysteamine (CysAm) for human tumor cells, the relationship between the expression of O6-methylguanine-DNA methyltransferase (MGMT) and cell sensitivity to CysAm, and apoptosis-inducing capacity of this preparation. It was found that histogenetically different cell lines are characterized by different sensitivity to CysAm, and this parameter correlated with the basal level of MGMT. CysAm induced apoptosis via activation of caspases 3 and 7. These data suggest that CysAm can be considered as a potential antitumor agent, but definitive conclusions can be made after preclinical trials. |
| Databáze: | OpenAIRE |
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