Lactate dehydrogenase changes following several cardiac hypertrophic stresses
| Autor: | D. G. Penney, J. W. York, P. A. Stagno, T. A. Weeks |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Male
medicine.medical_specialty Physiology Protein subunit Cardiomegaly Biology Left ventricular hypertrophy Isozyme Muscle hypertrophy chemistry.chemical_compound Right ventricular hypertrophy Physical Conditioning Animal Physiology (medical) Internal medicine Lactate dehydrogenase medicine Animals skin and connective tissue diseases Aorta L-Lactate Dehydrogenase Altitude Myocardium Organ Size medicine.disease Constriction Rats Isoenzymes Stenosis medicine.anatomical_structure chemistry Ventricle cardiovascular system Cardiology sense organs |
| Zdroj: | Journal of Applied Physiology. 40:923-926 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/jappl.1976.40.6.923 |
| Popis: | The effects of four different cardiac hypertrophic stresses on cardiac lactate dehydrogenase (LDH) isozyme composition and activity were examined. Altitude-induced right ventricular hypertrophy was accompanied by an increase of 10% in the M subunit of LDH in right ventricle, left ventricle, and atria. Left ventricular hypertrophy induced by aortic stenosis also produced isozyme changes in the ventricles, but of only half the magnitude. Biventricular hypertrophy, induced by running or swimming, was accompanied by 4–5% increases in M LDH in the ventricles only. We conclude that changes in LDH activity are directly related to changes in the M subunit in all three portions of the heart. No changes in H subunit were noted under any of the stresses. It appears that the magnitude of changes in cardiac LDH isozyme composition are only marginally related to extent of hypertrophy. |
| Databáze: | OpenAIRE |
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