Value of GPSkin for the measurement of skin barrier impairment and for monitoring of rosacea treatment in daily practice

Autor:	Elke M G J de Jong, Jade G M Logger, R.J.B. Driessen, Piet E.J. van Erp
Rok vydání:	2021
Předmět:	GPSkin medicine.medical_specialty Skin barrier capacitance Dermatology 01 natural sciences 010309 optics 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Body Water Forearm Daily practice 0103 physical sciences medicine Stratum corneum stratum corneum Humans skin hydration Barrier function Skin barrier function Skin Transepidermal water loss integumentary system business.industry transepidermal water loss Water Original Articles medicine.disease Water Loss Insensible medicine.anatomical_structure Rosacea skin barrier function Inflammatory diseases Radboud Institute for Health Sciences [Radboudumc 5] Original Article Epidermis business Inflammatory diseases Radboud Institute for Molecular Life Sciences [Radboudumc 5]
Zdroj:	Skin Research and Technology, 27, 15-23 Skin Research and Technology, 27, 1, pp. 15-23 Skin Research and Technology
ISSN:	0909-752X
DOI:	10.1111/srt.12900
Popis:	Contains fulltext : 235374.pdf (Publisher’s version ) (Open Access) BACKGROUND: Stratum corneum hydration (SCH) and transepidermal water loss (TEWL) provide useful information about skin barrier function. This study aimed to determine the value of GPSkin Pro, a new handheld device determining both SCH and TEWL, to measure skin barrier impairment and to monitor barrier function in rosacea in daily practice. MATERIALS AND METHODS: Two pilots were performed. Pilot 1: in 27 healthy participants, GPSkin SCH and TEWL were compared to Aquaflux(®) and Epsilon(®) values at the forearm before and after skin barrier perturbation via tapestripping. Moreover, GPSkin values were measured at both cheeks without intervention. Pilot 2: in 16 rosacea patients, GPSkin measurements were performed at the forearm, and at both cheeks before and during anti-inflammatory treatment. They were compared to clinical symptoms and to GPSkin values from pilot 1. RESULTS: Pilot 1: after merging data from before and after tapestripping, a strong correlation was observed between GPSkin TEWL and Aquaflux(®) (R(s) = 0.9256), and GPSkin SCH and Epsilon(®) (R(s) = 0.8798). Pilot 2: SCH was significantly lower at the cheeks of rosacea patients compared to controls, with a normalizing trend during successful treatment. TEWL was comparable among patients and controls and did not change during treatment at all locations. CONCLUSION: The GPSkin determines TEWL and SCH accurately in healthy and impaired skin barrier state and can monitor skin barrier function in rosacea during treatment. The GPSkin device is much more practical compared to previous skin barrier tools when used in clinical practice. Its further validation in other inflammatory skin diseases is recommended.
Databáze:	OpenAIRE
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