Effect of defensins-containing eye cream on periocular rhytids and skin quality
| Autor: | Angelique M. Berens, Shabnam Ghazizadeh |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Epidermal thickness Skin Cream Dermatology Skin thickness Skin Aging Defensins 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Medicine Humans In patient Prospective Studies Ultrasound scanner Skin integumentary system business.industry Outcome measures Middle Aged Structure and function 030220 oncology & carcinogenesis Patient survey Female Epidermis business |
| Zdroj: | Journal of cosmetic dermatologyREFERENCES. 19(8) |
| ISSN: | 1473-2165 |
| Popis: | BACKGROUND Defensins are peptides shown to activate LGR6 stem cells to stimulate the production of new basal stem cells in the epidermis. Use of topical definsin-containing products has been shown to address signs of global skin aging including decrease of wrinkles and increase of epidermal thickness. AIMS To investigate the ability of a topical defensin-containing skincare product in improving the structure and function of aging periocular skin using objective and subjective outcome measures. PATIENTS/METHODS A prospective pilot trial of a defensin-containing eye cream was performed in patients with periocular rhytids over 6 weeks. Subjective changes in skin quality and aging characteristics were compared using a patient survey tool. Objective changes in periocular skin quality were analyzed using the QuantifiCare imaging system and the DermLab ultrasound scanner by blinded reviewers. RESULTS A total of eight patients completed treatment; two were male, and six were female. The average age was 51 years (range 37-63). Compliance with product application as reported on the participant application log was over 90%. Overall, there was an average 2.1 point improvement in subjective measures of skin quality on the consumer questionnaire (P = .002). QuantifiCare imaging of pores, wrinkles, and oiliness showed 370% improvement, 55% improvement, and 12% improvement, respectively. DermaLab noninvasive measurements of elasticity, skin thickness, and hydration showed improvement of 120%, 28%, and 6%, respectively. CONCLUSION The use of topical formulations of definsin-containing eye cream statically improves patient-reported outcomes of skin quality, especially redness, sensitivity to weather, age spots, and crow's feet. |
| Databáze: | OpenAIRE |
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