Finished Genome of the Fungal Wheat Pathogen Mycosphaerella graminicola Reveals Dispensome Structure, Chromosome Plasticity, and Stealth Pathogenesis
| Autor: | Hank Tu, Ioannis Stergiopoulos, Igor V. Grigoriev, Jan P. H. Nap, Alexander H. J. Wittenberg, Kim E. Hammond-Kosack, Judith Bowler, Theo van der Lee, Stefano F.F. Torriani, Bernard Henrissat, Henri van de Geest, Bruno G. G. Donzelli, Natália F. Martins, Andrea Aerts, Pedro M. Coutinho, Rahim Mehrabi, Vincent Lombard, Hans J. Cools, James Bristow, Arnold Kuzniar, Gert H. J. Kema, James K. Hane, Cees Waalwijk, L.H. Zwiers, S.B. Ware, Blondy Canto-Canché, Paramvir S. Dehal, Roeland C. H. J. van Ham, Sarrah Ben M’Barek, Yiannis A. I. Kourmpetis, Pierre J. G. M. de Wit, Andrzej Kilian, Ronald P. de Vries, Chris Maliepaard, Charles F. Crane, Michael Csukai, Burt H. Bluhm, Laura Conde-Ferráez, Ad Wiebenga, Erika Lindquist, Richard P. Oliver, Alisa Ponomarenko, Asaf Salamov, Adilson Kenji Kobayashi, Stephen B. Goodwin, Edda Koopmann, Braham Dhillon, Henk J. Schouten, Jason J. Rudd, John F. Antoniw, Harris Shapiro, Alice C. L. Churchill, Andrew J Foster, Andy M. Bailey, Ate van der Burgt, Jane Grimwood, Jeremy Schmutz |
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| Přispěvatelé: | Malik, Harmit S, STEPHEN B. GOODWIN, USDA–AGRICULTURAL RESEARCH SERVICE, SARRAH BEN M’BAREK, PLANT RESEARCH INTERNATIONAL B.V., WAGENINGEN, THE NETHERLANDS, BRAHAM DHILLON, PURDUE UNIVERSITY, USA, ALEXANDER H. J. WITTENBERG, PLANT RESEARCH INTERNATIONAL B.V., WAGENINGEN, THE NETHERLANDS, CHARLES F. CRANE, USDA–AGRICULTURAL RESEARCH SERVICE, JAMES K. HANE, MURDOCH UNIVERSITY, PERTH, AUSTRALIA, ANDREW J. FOSTER, IBWF e.V., GERMANY, THEO A. J. VAN DER LEE, PLANT RESEARCH INTERNATIONAL B.V., WAGENINGEN, THE NETHERLANDS, JANE GRIMWOOD, HUDSONALPHA INSTITUTE OF BIOTECHNOLOGY, USA, ANDREA AERTS, DOE JOINT GENOME INSTITUTE, USA, JOHN ANTONIW, ROTHAMSTED RESEARCH, UNITED KINGDOM, ANDY BAILEY, UNIVERSITY OF BRISTOL, UNITED KINGDOM, BURT BLUHM, UNIVERSITY OF ARKANSAS, USA, JUDITH BOWLER, SYNGENTA, UNITED KINGDOM, JIM BRISTOW, HUDSONALPHA INSTITUTE OF BIOTECHNOLOGY, USA, ATE VAN DER BURGT, PLANT RESEARCH INTERNATIONAL B.V., WAGENINGEN, THE NETHERLANDS, BLONDY CANTO CANCHE, CENTRO DE INVESTIGACIÓN CIENTÍFICA DE YUCATÁN, MÉXICO, ALICE C. L. CHURCHILL, CORNELL UNIVERSITY, USA, LAURA CONDE FERRÀEZ, CENTRO DE INVESTIGACIÓN CIENTÍFICA DE YUCATÁN, MÉXICO, HANS J. COOLS, ROTHAMSTED RESEARCH, UNITED KINGDOM, PEDRO M. COUTINHO, ARCHITECTURE ET FONCTION DES MACROMOLECULES BIOLOGIQUES, CNRS, FRANCE, MICHAEL CSUKAI, SYNGENTA, UNITED KINGDOM, PARAMVIR DEHAL, DOE JOINT GENOME INSTITUTE, USA, PIERRE DE WIT, WAGENINGEN UNIVERSITY AND RESEARCH CENTRE, THE NETHERLANDS, BRUNO DONZELLI, USDA–AGRICULTURAL RESEARCH SERVICE, HENRI C. VAN DE GEEST, PLANT RESEARCH INTERNATIONAL B.V., WAGENINGEN, THE NETHERLANDS, ROELAND C. H. J. VAN HAM, PLANT RESEARCH INTERNATIONAL B.V., WAGENINGEN, THE NETHERLANDS, KIM E. HAMMOND KOSACK, ROTHAMSTED RESEARCH, UNITED KINGDOM, BERNARD HENRISSAT, ARCHITECTURE ET FONCTION DES MACROMOLECULES BIOLOGIQUES, CNRS, FRANCE, ANDRZEJ KILIAN, DIVERSITY ARRAYS TECHNOLOGY PTY LTD, AUSTRALIA, ADILSON KENJI KOBAYASHI, CPAMN, EDDA KOOPMANN, BAYER CROPSCIENCE AG, GERMANY, YIANNIS KOURMPETIS, WAGENINGEN UNIVERSITY AND RESEARCH CENTRE, THE NETHERLANDS, ARNOLD KUZNIAR, WAGENINGEN UNIVERSITY AND RESEARCH CENTRE, THE NETHERLANDS, ERIKA LINDQUIST, DOE JOINT GENOME INSTITUTE, USA, VINCENT LOMBARD, ARCHITECTURE ET FONCTION DES MACROMOLECULES BIOLOGIQUES, CNRS, FRANCE, CHRIS MALIEPAARD, WAGENINGEN UNIVERSITY AND RESEARCH CENTRE, THE NETHERLANDS, NATALIA FLORENCIO MARTINS, CENARGEN, RAHIM MEHRABI, SEED AND PLANT IMPROVEMENT INSTITUTE, IRAN, JAN P. H. NAP, PLANT RESEARCH INTERNATIONAL B.V., WAGENINGEN, THE NETHERLANDS, ALISA PONOMARENKO, PURDUE UNIVERSITY, USA, JASON J. RUDD, ROTHAMSTED RESEARCH, UNITED KINGDOM, ASAF SALAMOV, DOE JOINT GENOME INSTITUTE, USA, JEREMY SCHMUTZ, HUDSONALPHA INSTITUTE OF BIOTECHNOLOGY, USA, HENK J. SCHOUTEN, PLANT RESEARCH INTERNATIONAL B.V., WAGENINGEN, THE NETHERLANDS, HARRIS SHAPIRO, DOE JOINT GENOME INSTITUTE, USA, IOANNIS STERGIOPOULOS, WAGENINGEN UNIVERSITY AND RESEARCH CENTRE, THE NETHERLANDS, STEFANO F. F. TORRIANI, SWISS FEDERAL INSTITUTE OF TECHNOLOGY (ETH), SWITZERLAND, HANK TU, DOE JOINT GENOME INSTITUTE, USA, RONALD P. DE VRIES, CBS–KNAW FUNGAL BIODIVERSITY CENTRE, THE NETHERLANDS, CEES WAALWIJK, PLANT RESEARCH INTERNATIONAL B.V., WAGENINGEN, THE NETHERLANDS, SARAH B. WARE, PLANT RESEARCH INTERNATIONAL B.V., WAGENINGEN, THE NETHERLANDS, AD WIEBENGA, CBS–KNAW FUNGAL BIODIVERSITY CENTRE, THE NETHERLANDS, LUTE-HARM ZWIERS, CBS–KNAW FUNGAL BIODIVERSITY CENTRE, THE NETHERLANDS, RICHARD P. OLIVER, CURTIN UNIVERSITY, AUSTRALIA, IGOR V. GRIGORIEV, DOE JOINT GENOME INSTITUTE, USA, GERT H. J. KEMA, PLANT RESEARCH INTERNATIONAL B.V., WAGENINGEN, THE NETHERLANDS. |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Cancer Research
neurospora RRES175 Genome Graminicola Fungus PRI Biodiversiteit en Veredeling 2.2 Factors relating to the physical environment Aetiology Triticum Genetics (clinical) Gene Rearrangement Genetics PBR Kwantitatieve aspecten biology EPS-2 Fungal genetics food and beverages Agriculture Genomics organization symbiosis Fungal Infectious Diseases annotation host Mycosphaerella graminicola Zero Hunger Mycosphaerella Chromosomes Fungal Genome Fungal Infection Fungo Research Article Biotechnology 175_Genetics lcsh:QH426-470 Bioinformatics Synteny Chromosomes PBR Quantitative aspects of Plant Breeding resistance BIOS Applied Bioinformatics Ascomycota expression Bioinformatica 175_Plant sciences b-chromosomes gene Biology Molecular Biology Ecology Evolution Behavior and Systematics Plant Diseases B chromosome Biointeracties and Plant Health Bioint Moleculair Phytopathology magnaporthe-grisea Gene rearrangement biology.organism_classification 175_Fungi Laboratorium voor Phytopathologie PRI Biodiversity and Breeding lcsh:Genetics Plant Breeding Laboratory of Phytopathology PRI Biointeractions en Plantgezondheid Pest Control Developmental Biology |
| Zdroj: | Department of Botany and Plant Pathology Faculty Publications PLoS Genetics, 7 (6) Plos Genetics, 7(6) PLoS genetics, vol 7, iss 6 PLoS Genetics, Vol 7, Iss 6, p e1002070 (2011) PLoS Genetics Plos Genetics 7 (2011) 6 PLoS Genetics, 7(6), 1002070-1002070. Public Library of Science Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA-Alice) Empresa Brasileira de Pesquisa Agropecuária (Embrapa) instacron:EMBRAPA |
| ISSN: | 1553-7404 1553-7390 |
| DOI: | 10.1371/journal.pgen.1002070 |
| Popis: | The plant-pathogenic fungus Mycosphaerella graminicola (asexual stage: Septoria tritici) causes septoria tritici blotch, a disease that greatly reduces the yield and quality of wheat. This disease is economically important in most wheat-growing areas worldwide and threatens global food production. Control of the disease has been hampered by a limited understanding of the genetic and biochemical bases of pathogenicity, including mechanisms of infection and of resistance in the host. Unlike most other plant pathogens, M. graminicola has a long latent period during which it evades host defenses. Although this type of stealth pathogenicity occurs commonly in Mycosphaerella and other Dothideomycetes, the largest class of plant-pathogenic fungi, its genetic basis is not known. To address this problem, the genome of M. graminicola was sequenced completely. The finished genome contains 21 chromosomes, eight of which could be lost with no visible effect on the fungus and thus are dispensable. This eight-chromosome dispensome is dynamic in field and progeny isolates, is different from the core genome in gene and repeat content, and appears to have originated by ancient horizontal transfer from an unknown donor. Synteny plots of the M. graminicola chromosomes versus those of the only other sequenced Dothideomycete, Stagonospora nodorum, revealed conservation of gene content but not order or orientation, suggesting a high rate of intra-chromosomal rearrangement in one or both species. This observed “mesosynteny” is very different from synteny seen between other organisms. A surprising feature of the M. graminicola genome compared to other sequenced plant pathogens was that it contained very few genes for enzymes that break down plant cell walls, which was more similar to endophytes than to pathogens. The stealth pathogenesis of M. graminicola probably involves degradation of proteins rather than carbohydrates to evade host defenses during the biotrophic stage of infection and may have evolved from endophytic ancestors. PLoS Genetics, 7 (6) ISSN:1553-7390 ISSN:1553-7404 |
| Databáze: | OpenAIRE |
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