Synergistic effects of histologic subtype, T-stage, and M-stage in the prognosis of differentiated thyroid cancer: a retrospective observational study
| Autor: | Yihui Huang, Wei Zhou, Chao Zhang, Shipei Wang, Zeming Liu, Liang Guo, Ling Zhou, Wen Zeng, Min Wang, Sichao Chen, Di Hu, Wei Wei |
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| Rok vydání: | 2020 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty business.industry Retrospective cohort study Differentiated thyroid cancer medicine.disease SEER synergistic effect death Internal medicine medicine T-stage Original Article Radiology Nuclear Medicine and imaging Stage (cooking) business Thyroid cancer |
| Zdroj: | Translational Cancer Research |
| ISSN: | 2219-6803 2218-676X |
| Popis: | Background The incidence of differentiated thyroid cancer has increased in many countries during the past few decades. This study aimed to investigate the synergistic effect of clinicopathological factors, including histologic subtype, T stage, and M stage, on the prognosis of differentiated thyroid cancer (DTC). Methods We collected data on 86,302 patients with DTC from 2004 to 2013 from the SEER database. We extracted multiple variables from the selected object of study. Demographic characteristics consisted of age at diagnosis, sex, year of diagnosis, and race. Pathological characteristics included T stage, N stage, M stage, multifocality, histologic subtype and extrathyroidal extension. Treatment characteristics included radiation therapy and surgery. Univariate and multivariate analyses were conducted to evaluate the correlation between clinicopathological factors and prognosis. The relative excess risk of synergistic effect (RERI), attributable proportion (AP) of synergistic effect, and synergy index (SI) were used to explore the synergistic effect of these factors on prognosis. Results Histologic subtype, T-stage, and M-stage were found to be risk factors for cancer-specific survival and all-cause survival in multivariate analysis. The cancer-specific mortality (CSM) rates per 1,000 person-years for patients were found to be higher in follicular thyroid carcinoma (FTC) patients and patients with T3–T4, M1 status disease. In addition, CSM and all-cause mortality (ACM) were also associated with age, sex, race, N- stage, extension, radiation treatment, and surgical approach (all, P |
| Databáze: | OpenAIRE |
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