MTNR1B gene on susceptibility to gestational diabetes mellitus: a two-stage hospital-based study in Southern China
| Autor: | Aiyong Zhu, Yi Shen, Peng Zhang, Yuan-Lin Liu, Xuefeng Gu, Liying Jiang, Xiuying Shi, Yulong Jia |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
0106 biological sciences 0301 basic medicine Oncology China medicine.medical_specialty Genotype Population Single-nucleotide polymorphism Biology Logistic regression Polymorphism Single Nucleotide 01 natural sciences 03 medical and health sciences Asian People Pregnancy Internal medicine Genetics medicine Humans SNP Genetic Predisposition to Disease Allele education Molecular Biology Genotyping Genetic Association Studies education.field_of_study Receptor Melatonin MT2 General Medicine medicine.disease Gestational diabetes Diabetes Gestational 030104 developmental biology Melatonin receptor 1B Case-Control Studies Female 010606 plant biology & botany |
| Zdroj: | Molecular Genetics and Genomics. 295:1369-1378 |
| ISSN: | 1617-4623 1617-4615 |
| Popis: | Large-scale studies on genetic risk loci for melatonin receptor 1B (MTNR1B) gene and GDM risk have not been well generalized to the Chinese population. In this study, we performed two-stage case–control study: 1.429 pregnant women: 753 GDM/676 controls in the Southern Chinese population by genotyping 5 SNPs (rs10830963, rs1387153, rs2166706, rs1447352, and rs4753426) in MTNR1B. Genotypes were determined using the Sequenom MassARRAY platform and TaqMan allelic discrimination assay. Interactions between genetic variants and age/BMI as predictors of GDM risk were evaluated under the logistic regression model. In the first stage, the SNP rs10830963 was discovered to be potentially related to GDM risk (additive model: OR = 1.27, 95%CI = 1.05–1.55, P = 0.025), which was further confirmed in the second stage with a similar effect (additive model: OR = 1.53, 95%CI = 1.19–1.98, P = 0.005). In the combined stage, the G allele of rs10830963 was potentially associated with GDM risk (additive model: OR = 1.36, 95%CI = 1.17–1.59, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink