Efficacy and safety of intravitreal ranibizumab with panretinal photocoagulation followed by trabeculectomy compared with Ahmed glaucoma valve implantation in neovascular glaucoma
| Autor: | Meng An, Hai-Jing Liang, Da-Bo Wang, Jin-Tao Sun |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Intraocular pressure
medicine.medical_specialty genetic structures medicine.medical_treatment Panretinal photocoagulation Glaucoma valve 03 medical and health sciences 0302 clinical medicine lcsh:Ophthalmology Clinical Research Ophthalmology Occlusion medicine Trabeculectomy ranibizumab Ahmed drainage valve implantation neovascular glaucoma business.industry trabeculectomy Diabetic retinopathy medicine.disease panretinal photocoagulation eye diseases lcsh:RE1-994 030220 oncology & carcinogenesis 030221 ophthalmology & optometry sense organs Ranibizumab business Shallow anterior chamber medicine.drug |
| Zdroj: | International Journal of Ophthalmology, Vol 10, Iss 3, Pp 400-405 (2017) |
| ISSN: | 2227-4898 2222-3959 |
| Popis: | AIM: To evaluate the efficacy and safety of intravitreal ranibizumab (IVR) with panretinal photocoagulation (PRP) followed by trabeculectomy compared with Ahmed glaucoma valve (AGV) implantation in neovascular glaucoma (NVG). METHODS: This was a retrospective comparative study. We reviewed the cases of a total of 45 eyes from 45 NVG patients among which 23 eyes underwent AGV implantation and the other 22 underwent trabeculectomy. The causes of neovascular glaucoma included: diabetic retinopathy (25 eyes), and retinal vein occlusion (20 eyes). All patients received preoperative IVR combined with postoperative PRP. The mean best-corrected visual acuities (BCVA) were converted to the logarithms of the minimum angle of resolution (logMAR) for the statisitical analyses. Intraocular pressure (IOP), the logMAR BCVA and surgical complications were evaluated before and after surgery. The follow-up period was 12mo. RESULTS: A total of 39 cases showed complete regression of iris neovascularization at 7d after injection, and 6 cases showed a small amount of residual iris neovascularization. The success rates were 81.8% and 82.6% at 12mo after trabeculectomy and AGV implantation, respectively. In the trabeculectomy group, the logMAR BCVA improved at the last follow-up in 14 eyes, remained stable in 6 eyes and decreased in 2 eyes. In 4 cases, slight hyphemas developed after trabeculectomy. A shallow anterior chamber developed in 2 cases and 2 vitreous hemorrhages. In the AGV group, the logMAR BCVA improved in 14 eyes, remained stable in 5 eyes and decreased in 4 eyes. Slight hyphemas developed in 3 cases, and a shallow anterior chamber in 3 cases. The mean postoperative IOP was significantly lower in both groups after surgery (F=545.468, P |
| Databáze: | OpenAIRE |
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