HLA-DRB1* and DQB1* allele and haplotype diversity in eight tribal populations: Global affinities and genetic basis of diseases in South India
| Autor: | K V Darsa, Padma-Malini Ravi, Vandit Sevak, Sasiharan Pandi, Prabhakaran Krishnan, Rathika Chinniah, Murali Vijayan, Balakrishnan Karuppiah, Nandakumar Rangasamy, Ramgopal Sivanadham |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male 0301 basic medicine Microbiology (medical) 030106 microbiology Population India Human leukocyte antigen Immunogenetics Biology Microbiology Evolution Molecular 03 medical and health sciences Gene Frequency Ethnicity Genetics HLA-DQ beta-Chains Humans Genetic Predisposition to Disease Allele education Molecular Biology HLA-DRB1 Phylogeny Ecology Evolution Behavior and Systematics education.field_of_study Phylogenetic tree Dendrogram Haplotype Middle Aged 030104 developmental biology Infectious Diseases Haplotypes Female HLA-DRB1 Chains |
| Zdroj: | Infection, Genetics and Evolution. 89:104685 |
| ISSN: | 1567-1348 |
| Popis: | The distribution of HLA class-II DRB1* and DQB1* alleles/ haplotypes were studied in 438 individuals of 8 Dravidian tribal groups inhabiting the Western Ghats, south India. The HLA typing was performed by PCR-SSP method. In order to identify the 5-locus Ancestral Extended Haplotypes (AEH), the alleles of HLA-A, -B and -C loci were typed for DNAs with predominant 2-locus haplotypes. The analyses have revealed allele HLA-DRB1*15 as the most predominant allele (Lowest / Highest range: Urali, 14.81 / Malasar, 48.94), followed by the alleles DRB1*10 (Katunayakan, 1.85 / Paliyan, 48.21), DRB1*14 (Paliyan 4.46 / Katunayakan, 40.74), DRB1*12 (Mannan, 1.64 / Katunayakan, 20.37) and DRB1*03 (Mannan, 1.64 / Urali, 29.63). The most frequent DQB1* alleles were DQB1*02 (Paliyan 3.57 / Urali, 23.15), DQB1*05 (Katunayakan, 27.77 / Paliyan 84.82) and DQB1*06 (Malasar, 8.51 / Kuruman, 33.51). The most predominant two-locus haplotypes observed were DRB1*15-DQB1*05, DRB1*10-DQB1*05, DRB1*15-DQB1*06 and DRB1*04-DQB1*05. The present study of HLA immunogenetics of south Indian tribes have revealed the presence of globally shared two and 5-locus haplotypes. Many of these haplotypes were implicated in a number of diseases in south India. We observed the presence of ancestral extended haplotypes (AEHs), hitherto not reported in Indian populations such as, A*68-B*35-C*02-DRB1*15:01-DQB1*05:01, A*24-B*57-C*06-DRB1*04:01-DQB1*05:01 and A*24-B*35-C*02-DRB1*15:01-DQB1*05:02. The dendrogram based phylogenetic analyses have revealed the Caucasian affinity of Urali, palaeo-Mediterranean and Indo-European affinity of Malasar tribes. The presence of globally shared susceptible and protective haplotypes reiterated the mosaic immunogenetic fabric of south Indian tribes. |
| Databáze: | OpenAIRE |
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