Efficacy of Ciprofloxacin and Moxifloxacin against Nocardia brasiliensis In Vitro and in an Experimental Model of Actinomycetoma in BALB/c Mice

Autor:	Norma Cavazos-Rocha, Lucio Vera-Cabrera, María de la Luz Salazar-Cavazos, Hector Gerardo Garza-Lozano, Salvador Said-Fernández, Jorge Ocampo-Candiani, Oliverio Welsh, Brenda Edith Chacon-Moreno
Rok vydání:	2009
Předmět:	medicine.drug_class Moxifloxacin Antibiotics Microbial Sensitivity Tests Nocardia BALB/c Microbiology Mice Ciprofloxacin medicine Animals heterocyclic compounds Experimental Therapeutics Pharmacology (medical) Antibacterial agent Pharmacology Aza Compounds Mice Inbred BALB C biology Nocardia brasiliensis biochemical phenomena metabolism and nutrition bacterial infections and mycoses biology.organism_classification Actinomycetoma Disease Models Animal Infectious Diseases Mycetoma Quinolines Female Fluoroquinolones medicine.drug
Zdroj:	Antimicrobial Agents and Chemotherapy. 53:295-297
ISSN:	1098-6596 0066-4804
DOI:	10.1128/aac.01023-08
Popis:	The efficacy of ciprofloxacin and moxifloxacin against Nocardia brasiliensis was evaluated by applying 25 mg of each drug/kg subcutaneously every 8 h in BALB/c mice infected with N. brasiliensis . A statistically significant difference was observed only with moxifloxacin. A moxifloxacin-trimethoprim-sulfamethoxazole combination was as active as when each compound was used alone.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ad215c3564faac2a6f87dadae9b12f https://doi.org/10.1128/aac.01023-08 Zobrazit plný text záznamu