Epidemiology and Outcome of Sepsis in a Tertiary Care PICU of Pakistan
| Autor: | Farah Naz Qamar, Komal Masood, Prem Kumar Maheshwari, Muhammad Rehan Khan, Anwarul Haque |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Critical Care Multiple Organ Failure Intensive Care Units Pediatric Logistic regression Tertiary care Hospitals University Tertiary Care Centers Sepsis Epidemiology Humans Medicine Pakistan Hospital Mortality Child Developing Countries Retrospective Studies Pediatric intensive care unit business.industry Septic shock Infant Retrospective cohort study Specific mortality medicine.disease Combined Modality Therapy Logistic Models Treatment Outcome Child Preschool Pediatrics Perinatology and Child Health Emergency medicine Female business |
| Zdroj: | The Indian Journal of Pediatrics. 79:1454-1458 |
| ISSN: | 0973-7693 0019-5456 |
| DOI: | 10.1007/s12098-012-0706-z |
| Popis: | To determine the epidemiology and outcome of sepsis in children admitted in pediatric intensive care unit (PICU) of a tertiary care hospital. Retrospective review of children 1 mo to 14 y old, admitted to the PICU with severe sepsis or septic shock from January 2007 through December 2008 was done. Demographic, clinical and laboratory features of subjects were reviewed. The primary outcome was mortality at the time of discharge from PICU. The independent predictors of mortality were modeled using multiple logistic regression. In 2 years, 17.3% (133/767) children admitted to the PICU had sepsis. Median age was 18 mo (IQR 6–93 mo), with male: female ratio of 1.6:1. Mean PRISM III score was 9 (±7.8). One third had culture proven infection, majority (20%) having bloodstream infection. The frequency of multi-organ dysfunction syndrome (MODS) was 81% (108/133). The case specific mortality rate of sepsis was 24% (32/133). Multi-organ dysfunction (Adjusted OR 18.0, 95% CI 2.2–144), prism score of >10 (Adjusted OR 1.5, 95% CI 0.6–4.0) and the need for > 2 inotropes (Adjusted OR 3.5, 95% CI 1.3–9.2) were independently associated with mortality due to sepsis. The presence of septic shock and MODS is associated with high mortality in the PICU of developing countries. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink