Prostate cancer risk and consumption of fish oils: A dietary biomarker-based case–control study
| Autor: | C M Skeaff, Rod Jackson, G L B Arribas, S J Sharpe, Alan E. Norrish |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male eicosapentaenoic acid Cancer Research medicine.medical_specialty Erythrocytes Docosahexaenoic Acids Population Physiology Prostate cancer Risk Factors Internal medicine Biomarkers Tumor Humans Medicine Risk factor education Aged Aged 80 and over chemistry.chemical_classification education.field_of_study Dose-Response Relationship Drug business.industry Prostatic Neoplasms Regular Article docosahexaenoic acid Middle Aged Fish oil medicine.disease Eicosapentaenoic acid Endocrinology Oncology chemistry Docosahexaenoic acid Relative risk Multivariate Analysis biomarker diet business Polyunsaturated fatty acid |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/sj.bjc.6690835 |
| Popis: | Experimental studies suggest that the risk of prostate cancer is reduced with the intake of long-chain n-3 polyunsaturated fatty acids derived from marine foods, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). However, few human studies have been conducted due to difficulties in assessing the dietary intake of these fatty acids. The authors examined the relationship between prostate cancer risk and EPA and DHA in erythrocyte biomarkers in a population-based case–control study in Auckland, New Zealand during 1996–1997 involving 317 prostate cancer cases and 480 age-matched community controls. Reduced prostate cancer risk was associated with high erythrocyte phosphatidylcholine levels of EPA (multivariate relative risk = 0.59; 95% confidence interval 0.37–0.95, upper vs lowest quartile) and DHA (multivariate relative risk = 0.62; 95% confidence interval 0.39–0.98, upper vs lowest quartile). These analyses support evidence from in vitro experiments for a reduced risk of prostate cancer associated with dietary fish oils, possibly acting via inhibition of arachidonic acid-derived eicosanoid biosynthesis. © 1999 Cancer Research Campaign |
| Databáze: | OpenAIRE |
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