Serum humanin concentrations in women with pre-eclampsia compared to women with uncomplicated pregnancies
| Autor: | Dimitrios Vavilis, Georgios Tzimagiorgis, Dimitrios G. Goulis, Fani Chatzopoulou, Panagiotis Nikolakopoulos, Leonidas Zepiridis |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult medicine.medical_specialty 030204 cardiovascular system & hematology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pre-Eclampsia Pregnancy Internal medicine medicine Humans Humanin Creatinine Eclampsia Obstetrics business.industry Intracellular Signaling Peptides and Proteins Obstetrics and Gynecology Odds ratio medicine.disease Confidence interval 030104 developmental biology Endocrinology Blood pressure Cross-Sectional Studies chemistry Case-Control Studies Pediatrics Perinatology and Child Health Uric acid Female business Body mass index |
| Zdroj: | The journal of maternal-fetalneonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 31(3) |
| ISSN: | 1476-4954 |
| Popis: | To compare serum humanin concentrations in pregnant women with and without pre-eclampsia (PE).A case-control study where pregnant women (PE group, n = 37; control group, n = 34) studied through history parameters (gynecological, obstetrical, personal, and family), physical and sonographic examination parameters [body mass index (BMI), blood pressure obstetrical ultrasound], and biochemical/hormonal assays [creatinine, urea, serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), uric acid, platelets, urinary protein, and humanin].There was no difference in basic characteristics between women with PE and control, except in parity and gravidity. Humanin concentrations were higher in women with PE compared to controls (422.2 ± 33.5 vs. 319.1 ± 28.1 pg/ml, p = 0.023). In a binary logistic analysis, humanin was associated with the presence of PE [odds ratio 1.003, 95% confidence interval (CI); 1.000-1.006]. The ability of humanin to discriminate between women with PE and controls was evaluated by receiver operation characteristics (ROC) analysis [area under the curve (AUC) 0.639, 95% CI; 0.510-0.768, p = 0.045].Serum humanin concentrations are increased in women with PE, compared to women with uncomplicated pregnancies, suggesting a potential protective role of humanin against the oxidative stress and endothelial dysfunction occurring in PE. |
| Databáze: | OpenAIRE |
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