Life-Threatening Intracranial Bleeding in a Newborn with Congenital Cytomegalovirus Infection: Late-Onset Neonatal Hemorrhagic Disease
| Autor: | Gonul Gulal, Bulent Alioglu, Tülin Çataklı, Yıldız Dallar, Yavuz Sayar, Beray Selvar, Ülkü Tiraş |
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| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Anemia Late onset Disease Gastroenterology Cholestasis Internal medicine Vitamin K deficiency medicine Coagulopathy Humans Ganciclovir Prothrombin time medicine.diagnostic_test business.industry Infant Hematology Vitamin K Deficiency Bleeding medicine.disease Oncology Cytomegalovirus Infections Injections Intravenous Pediatrics Perinatology and Child Health Immunology Prothrombin Time Etiology Female business Intracranial Hemorrhages |
| Zdroj: | Pediatric Hematology and Oncology. 28:78-82 |
| ISSN: | 1521-0669 0888-0018 |
| DOI: | 10.3109/08880018.2010.513032 |
| Popis: | The authors present a case of a 36-day-old infant with intracranial and intramuscular hemorrhage due to vitamin K deficiency bleeding, who received intramuscular vitamin K prophylaxis at birth. In this case, laboratory tests showed anemia, liver dysfunction with cholestasis, and coagulopathy, consistent with vitamin K deficiency abnormality. Serological analyses showed that cytomegalovirus immunoglobulin (Ig)M and IgG avidity were both positive. The infant was treated successfully with intravenous ganciclovir and blood products. This case suggests that it is imperative to meticulously investigate the etiology in neonates with late-onset hemorrhagic disease of the newborn. Cholestatic liver disease caused by congenital cytomegalovirus infection should be in mind in term infants who presented with late-onset hemorrhagic disease. |
| Databáze: | OpenAIRE |
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