Hepatic microsomal glucose-6-phosphatase system and sudden infant death syndrome
| Autor: | Robert Hume, Anthony Busuttil, JeanneE. Bell, Ann Burchell |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
medicine.medical_specialty
Hepatic glycogen Glycogen Storage Disease Type I Internal medicine medicine Glycogen storage disease Humans biology business.industry Infant Newborn Infant General Medicine Sudden infant death syndrome medicine.disease Transport protein Liver Glycogen Endocrinology Liver T2 Deficiency Microsome biology.protein Glucose-6-Phosphatase Microsomes Liver Antibody business Glucose 6-phosphatase Sudden Infant Death |
| Zdroj: | Lancet (London, England). 2(8658) |
| ISSN: | 0140-6736 |
| Popis: | Microassay techniques and monospecific antibodies were used to study the hepatic glucose-6-phosphatase system in liver samples from 55 infants who had died suddenly and unexpectedly, including 38 victims of sudden infant death syndrome (SIDS). Raised hepatic glycogen was found in 10, all of whom had a diagnosis of SIDS, and in 1 other infant who was already known to have type 1b glycogen storage disease (deficiency of transport protein T1). Of the 10 infants with raised hepatic glycogen who had a diagnosis of SIDS, 8 had glucose-6-phosphatase deficiency (type la glycogen storage disease), and 2 had transport protein T2 deficiency (type 1c glycogen storage disease). |
| Databáze: | OpenAIRE |
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