Prevalence and risk factors associated to pruritus in Plasmodium vivax patients using chloroquine in the Brazilian Amazon
| Autor: | Marcus V. G. Lacerda, Aline C B Orlando, Maria das Graças Costa Alecrim, Priscilla C Ballut, André M. Siqueira, Márcia A. A. Alexandre |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Side effect Adolescent Drug-Related Side Effects and Adverse Reactions Veterinary (miscellaneous) Plasmodium vivax Antimalarials Young Adult Chloroquine Risk Factors Internal medicine parasitic diseases medicine Malaria Vivax Prevalence Humans Adverse effect skin and connective tissue diseases Child Aged biology integumentary system business.industry Pruritus Plasmodium falciparum Odds ratio Middle Aged biology.organism_classification medicine.disease Discontinuation Infectious Diseases Cross-Sectional Studies Insect Science Child Preschool Immunology Parasitology Female business Malaria Brazil medicine.drug |
| Zdroj: | Acta tropica. 128(3) |
| ISSN: | 1873-6254 |
| Popis: | Chloroquine-induced pruritus has been described as a common adverse event in African patients being treated for Plasmodium falciparum malaria, and has been associated with treatment discontinuation in this setting. In Latin America, where Plasmodium vivax is the most common species causing malaria and chloroquine is still used as the first-line schizonticidal for treating this parasite infection, there are no reports on chloroquine-induced pruritus. This study aimed to estimate the frequency of pruritus and associated risk factors in P. vivax-infected patients treated with chloroquine in a reference centre in the Brazilian Amazon. In this cross-sectional study, patients who were prescribed with chloroquine for the treatment of microscopy-confirmed P. vivax infection in the past five days were actively asked about the occurrence of any level of pruritus and potential risk factors were investigated. Univariable and multivariable logistic regression was performed for the analysis of possible risk factors in two sets of patients: (1) all the patients interviewed and (2) restricted to patients with previous use of chloroquine. Among the 510 patients interviewed, 20.4% (95%CI: 16.9-23.9%) developed any level of pruritus during treatment with chloroquine. Most episodes of pruritus occurred during the first two days of treatment and the most common location was hands and feet. In multivariate analysis performed in the entire population, the only risk factors independently associated to pruritus were allergy history (adjusted odds ratio [AOR]: 1.83; 95%CI 1.02-3.31; p=0.044) and high parasitaemia (AOR: 1.96: 95%CI 1.22-3.13; p=0.005). In the analysis restricted to the 215 patients with previous use of chloroquine, previous chloroquine-induced pruritus was a strong predictor of pruritus occurrence (AOR: 11.84: 95%CI 3.15-44.47; p |
| Databáze: | OpenAIRE |
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